ID A0A087YK20_POEFO Unreviewed; 1662 AA.
AC A0A087YK20;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSPFOP00000018373.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018373.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000018373.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01007764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007559376.1; XM_007559314.2.
DR STRING; 48698.ENSPFOP00000018373; -.
DR Ensembl; ENSPFOT00000018395.2; ENSPFOP00000018373.2; ENSPFOG00000018124.2.
DR GeneID; 103142973; -.
DR KEGG; pfor:103142973; -.
DR CTD; 10788; -.
DR eggNOG; KOG2128; Eukaryota.
DR GeneTree; ENSGT00950000183076; -.
DR OMA; CANKYYD; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR GO; GO:0072015; P:podocyte development; IEA:Ensembl.
DR CDD; cd05131; RasGAP_IQGAP2; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 41..156
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 684..711
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1002..1235
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 259..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1411..1443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1662 AA; 189434 MW; 946F2A7804FFF8AA CRC64;
MYHEETTMLQ RPRYGTIEDD ERLSAEQMDE RRRQNIAYEY LCHLEEAKRW MEACLDEGLP
PTTELEEGLR NGVYLGKLAN FFAPKLVSAK KIYDRDQARY KSKGLHFRHT DNTVQWLRAM
ESVGLPKIFY PETTDVYDRK NMPKVVYCIH ALSLYLYKLG IAPQIQDLLG KVAFTEEEIS
NMRSELDKYG IQMPAFSKIG GILANELSVD EAALHAAVIA INEAVERDHA SVTMGALQNP
NAMLRNTQEV LAQGYQDTLK QDKARKRDQS SGRRSSVATE ERDVYEELLT QQEIQTCIDR
VNTQAAVQNV NEAVLLQDEA ALLAALRLEA LSLLGVQDAN GGWYLEHFTT YIQQKSKNGG
RSVVLDKEEI HRIISTCNDF AEAEKRKLEA VARINTAIRL GSAVETVEEL LHPEAQLPIV
YQSAANLYQA ELFSLQLQGG RSGLSHEELS VAVEMLSAVA VLNEVLDTKD PQAVIEQLTD
SPLGFTNIEH DNLNRYADML IEERAETLSR SQEFLTWNDV QKCIDMVNIQ VQEEHERIIA
IAEINEALNS GDHRQTLAAL LLPTAKLTGV NPATSKHYHD VLHYSKHLLC QSSGDESAVL
WLDQIQEAVL TANQDEEEAL TMAGAVAHIN TTVEEGDSQK TLQALQIPSA GLRAVHPDCA
DAYQAELAQR QTANASKGSS DGVWVKHSIK DRYDYFYNLE TGQGSWEEPE GFEQKADQLS
KEEIQSVVNS VTAEYNREQL WLANESFVTQ LQARIRGHLA RKKYLQRMEY LRQQEPHVVK
IQACFRGYRQ RKIYIARINL LQKSVASVVK IQSIVKMWKA KRKYNQRLQF FREHEKEIVK
IQAFLKANKA RDDYRTLTGA SDPPLSVVRK FVHLLEQSPL DLQEEQEVTQ LREEVVTKIR
SNQQMEKDLN LMDIKIGLLV KNRITLQDVI SHNKKMKNKK NKTSKDDQTA GDGLGIKGLN
KGKRRKLEAY QHLFYLLQTI PSYLAKLIFQ MPQNKSTKFM DTVIFTLYNY ASNQREEYLL
LKLFKTALEE EINSKVDQIQ DIVTGNPTVI KMVVSFNRGA RGHNTLRQLL APVVKEIIDD
KSLGINTNPV DVYKAWVNQL ETATGEASKL PYEVTPEQAM SHEEVRNRLQ ASSVVLRSAT
DKMLNSIVSS LDNIPYGMRY IAKVLKNSLH EKFPEASEDE LLKIVGNLLY YRYMNPAIVA
PDGFDIIDMS AGGQLHVDQR RNLGSIAKML QHAAANKLFE GENEHMTPMN NYISQTYEKF
RLFFQAACDV PEPEEKFNVD EYSDMVTLSK PVIYISIEEI INTHSLLLEH LEAISPDQND
LLHELLQDLG DVPDVETLLG EGAVDPDDPN REATLSQLAK TEISLTLTNK FELLEGDDKD
LKTLMTKTKK LIVDVVRIQH GETLPEILET PATAPQESEH TKIVQRRADQ DAQTPEGLKS
SPAVLEDSQL PLEQKKRKIL RNLRNLEQAG LVTASNKYQD LINDIAKDIR YQRRYRQRRK
AELTKLQQTL TALNSKTDFF QEQMNYYDTY IKTCLDNLNR KNTRRSIKLD SKGEEKGSKK
WKPQSLKYTA ARLHEKGVIL EIEGLQTNQF KNVMFDISPT EEVGDFEVKA KFMGVEMEKV
QLHFQDLLQL QYEGVAVMKM FDKAKVNVNL LIFLLNKKFY GK
//
