ID A0A087YK97_POEFO Unreviewed; 1414 AA.
AC A0A087YK97;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIN2C {ECO:0000313|Ensembl:ENSPFOP00000018450.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018450.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000018450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; AYCK01010494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007565061.1; XM_007564999.2.
DR STRING; 48698.ENSPFOP00000018450; -.
DR Ensembl; ENSPFOT00000018472.1; ENSPFOP00000018450.1; ENSPFOG00000018336.1.
DR GeneID; 103146902; -.
DR KEGG; pfor:103146902; -.
DR CTD; 100003342; -.
DR eggNOG; KOG1053; Eukaryota.
DR GeneTree; ENSGT00940000156964; -.
DR OMA; FPIHYGD; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR CDD; cd06378; PBP1_iGluR_NMDA_NR2; 1.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF405; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 34..1414
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027150121"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 643..666
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 832..854
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 454..810
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 462..514
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 1033..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1414 AA; 158806 MW; 626FB3A17EA130AA CRC64;
MGLRLGSWSD SLWWPPPLPL LLLLLCTTPS CLGRPFGFPV PSVNVAVVFS GPAYQTEIKG
RLSRENFMDL PLEVNPITVL VNNTNPRALL TRICDTLSTN RVHGVVFEDN VGSEAVAQIL
DFISTQTAVP IVGISGGSAV VLPYKGEGSN FLQLGSSVEQ QINGMFKVME EYNWDSFVVI
TSLYPGYEAY VDYVKSFTDT SYFMWDLQDV LSFDMSADST NDIRARRLLQ QIDAQVLLVY
CSHEEAQYLF SLATEVGLIG PGYIWIIPSM AVGNPDIPPP DSFPVGLISI ITDRWRMSLR
KRVRDGVAIV VKGVQSFRKQ RGFIPEGHSD CHNPVKQSAI NDTLFRHMLN VTWEHNDFSF
NSNGYLVNPA MIVITLDRER QWDKVGTYEM GILQMRYPVW PRFGSYLEPV SDYRHLTVAT
LEERPFVIVE AVDPVTGTCV SNTVPCRRQS NKTEAIVGHT EPYTKLCCKG FCIDILKKLS
RTIKFSYDLY LVTNGKHGKL VRGIWNGMIG EVFYKRADMA IGSLTINEER SEIIDFSVPF
VETGISVMVA RSNGTVSPSA FLEPYSPAVW VMMFVMCLTV VAITVFVFEY CSPVGYNRSL
VSAKDPGGPT FTIGKSVWLL WGIVFNNSVP IENPKGTTSK IMVLVWAFFA VIFLASYTAN
LAAFMIQEQY IDTVSGLSDK KFQKPQEQYP PFRFGTVPNG STERNIRSNY PEMHSHMVKY
NQKGVEDALN SLKTGKLDAF IYDAAVLNYM AGKDEGCKLV TIGSGKVFAT TGYGIALQKD
SRWKRPIDLA LLQFLADGDT QKLQTVWLTG ICRNEKKEVM SSKLDIDNMA GVFYMLLVAM
GLSLLVFAWE HLLYWKLRHS VRKSDRLDFL LAISRGIYSC FNGVEQTDHN GSLQSPDVTT
NYTQANMLKM LRTAKDMVSS ARVENSLDSA TKTIENWSRR GADNVRAGLP PRVTTTDVTH
GRLPYISSIT DNHSPYPQRA ITPTFPVHYG DTSTQPLLEK PRVVTRPTPL RYTLPTRSSQ
HLLERTLPIS SLSSPHIAMR DPTPSGTSNP HHSSRLYVEN QGRHPASPFV SYREFQVPDI
YVEHKGPLRR KFSYPPDCVS RRRRSFSYLF NNPEPRVRVD YDEPRSCFAE LRANHLLNNQ
VPDGMAMACT PGHYPGSSTS CNSCMKSYLE PEMDEIPLLG KDKLNRRASF LKATWGNDRI
RQVDETKPST STAPSTRTDM PDLFPQVVGP NPKPHRLYGS LGHNLSCYPL AAEPAYLDPA
HMGSYPYKQK IKYADSTRLP SYREAILQNA AALRRSSSTV VHRHYSTYLN SYTDLPVYVG
PLPQGPSQFY NSSKDMCHLF PCTSHCPENT AMLPRMTGRP VAYHNNMFGP YDGPKREDLG
SGSRDRRQVL VARRVNSPYV PKPWGRVSSL ESEV
//
