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Database: UniProt
Entry: A0A087YKM4_POEFO
LinkDB: A0A087YKM4_POEFO
Original site: A0A087YKM4_POEFO 
ID   A0A087YKM4_POEFO        Unreviewed;      4896 AA.
AC   A0A087YKM4;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   28-MAR-2018, entry version 24.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSPFOP00000018577};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018577, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000018577, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000018577};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000018577}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AYCK01001842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000018599; ENSPFOP00000018577; ENSPFOG00000018441.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; THEKWSL; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4233   4250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4436   4455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4501   4522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4696   4718       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4777   4800       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    216       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      225    280       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      354    410       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      606    805       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1022   1220       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1265   1481       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3963   3998       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      474    494       {ECO:0000256|SAM:Coils}.
FT   COILED     3254   3274       {ECO:0000256|SAM:Coils}.
FT   COILED     3633   3653       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4896 AA;  552397 MW;  EF0BEE9FEB6CE07E CRC64;
     MTATGEAEDE GQFLRTGDEV VLQSTFTSHN EHLKLCLAAE GFGSRLCRLE PTSNCKNVPP
     DLSVCGFILA QCLSVRALQE MLAHSEQLAA EGSKAKAGVA HRTLLYGQAV MFTHSFSGLY
     LSCLSSSQTS PDKLAFDVGL QEDKAGEACW WTVHPASRQR SEGEKVRVGD DLILVSVSSE
     RYLHLSFAPV SDNKSLSDSL IVSASFQQTL WSVAPICSGG AIAQAGYLKG GETLRLLHSH
     SDACLTIPCS EQGEELQRVM HYEIGSVSGH GRSLWRLEIL HVAWSGRHTC WGEPFRLCHV
     TTGRYLCLTE ENGLHLVDRD KANINTTSFC FRSSKVKQEK LDAGKNTNSD CMGIPEIKYG
     DSMCYLQHLY SGLWLTYQAT DAKCRLGGNV RKAILHSEGH MDDGLTLSRS QREESHTAGL
     IRNTVSLFTR FIRKLDCFSH EGSLSSLCLP MKTVTCSLQD LIKYFQSPLD GQSHEDKQKK
     MAALRKRQNM FKEEGVIDLV LDCIDHLHHY SSDSSITDPA QWEAVVHLFY ELLAALIRGN
     RVNCAHFSSS VDWLIGRLDH LEASSGVLEV LHCVLVESPE AINVIKDGHI QSIISFLEKH
     GHDNKVLEVL CSLCVCHGVA VRSNQNLICD SLLPDRDLLL QTRLTNQVTS MRANIFLAMG
     EASAQHRRWY YELVVDHADP FLTAEPTHLR VGWAFTKGYL PRPTGGERWG GNGVGDDLYS
     FGFDGLHLWS GCVGRKVSSP FSHLLKDNDV VSCCLDLTVP CISFRVNGLP VQGMLENFNA
     NGLLYPVVSF SAGVRVRFLF GGGHGEFRFL PPPGYASCSE ALLPKVKLRV EPCQKYISDC
     EEGKKELIGP SVPVTPLTFT PTPVDISKVV LPPQLEDIRE KMAENFHELW VKDRIDLGWT
     NGPVKDEGKQ HDPCLVEFSK LPEQERNQNL HMAEDILKTV LALGFHIGLA DDHAEERVKY
     TRLHTKYELP CGYRPAPIDL RQITLSSADK DVVTLLAENH HNIWARERIK QGWTYGPEQD
     IKGKRSPHLV PYSLVDERMR KAGMESVREA VRLLLAFGYS LESLSQEQTP LSKPCLFSVE
     KSRVFRPDKS YAVTMGKWYF EFEVLTAGNM RVGWARPGCA PDKELGSDDQ AYVFDGFEAQ
     WCHQGGEPLG RRWLRGDVVG CLVDMFEGTM MVTLNGELLF NDRGSELAAK DLDVGDGGLL
     PVVSVGVNQV GRMNLGRQVE SLQYFNVCGQ QEGYKPFAFN MTRDPSLWMS WKLPLFTSVL
     PDDHSLQVTR RRGSMDSLSS LRVSQRAFVQ HGGGSEMGFY RLSMPIQCAA TLRSPAEGGL
     QVPSSSLTPS SGLEALPAER TPTEYYYAVR ILPGQEPFSV WIGWVTSDFH HHGSTFDTDS
     VGTVTVTLGD DSGKVQESVK RSNCFVVCAG EATGLSQSRR SAGLEIGCLI DTATGLLTFT
     SNGIEMSTFF QLEAGTKLFP AVFVKPTTTN MFQFELESIQ NAMPLSSAFL RGQRRNPSPQ
     CPPRFQVQYL KPVTWTRVPD GGLKVFVDWP DEHHGWRVQC FDPQQVMTLQ IPDENRCVDI
     LELSELDDLL SFHQNVLLLY CSLCALGNTR VCHALCSHVD QSQILYAIQN PHLAGPLRLA
     YYQLFIQVYL SSHTTACLTM NHEYIIPMTD QTAQASFYLG PVVGVSDGGN GQTPEGTCRS
     TCLKPQMCFS SPCFVRGDGM EAEDSPEIPL DTLRNLTADM LTAGVVAVGQ AVRDPAGGSV
     ELLLVPLLRL FYNLLVMGVF EDEDLVRVLR LIEPNVFSKN VKTVEEAKDG KQRGESINIK
     DDAIKQGLLQ MELPEPVQLE LCHLLSYLCD CQVRHRVEAV TAFSGNFVRQ LQENQRFRYT
     QVMQALNMSA ALTARKTKEF RLPPQEQKIS HREKINLLLS FREDEQQENC PCPVELQQLL
     HDFHHLLNTH CGTKTVPDSE EEDDTKMSLK DRLFSRAAKA VGLKKKPAEV EKYKSPKLKS
     LRRLISDMTV CWAQEREIED PELVRAIFTL LHRQYQGLEG QMEGSLSKAY AISQSSVEDT
     MALLSSLGQI RSLLSVRMGK EEEKLMIRKL GDIMNNKVFY QHPNLMRSLG MHETVMEVMV
     HVLGEGESKE ITFPKMVASC CRFLCYFCRI SRHNQGALFD RLSYLLENSR VGLASPSMRG
     STPLDVAAAS VMDNNELALS LKEADLEKVV QYLAGCGLQS CSLLLAKGYT DIGWNPVEGE
     RYVDFLRFAV FCNGESVEEN AYVVLRLLIR RPECFGPALR GDGGDGLLAA MKEAISISQD
     PSMDGPFPTQ HPSKTTYRDG VHSNEDDLIH MGHAIMTFYS ALIDLLGRCA PEMHLIQGGK
     GEAIRIRAIL RSLIPVQDLE GVISICFQLP SVSEDGVLVE PDLSTAFCPD HKAAMVLFLD
     RVYGVESQRF LLHLLEVGFL PDLHAAVSLD TTDLGSTDMA LALNRYLCTA VLPLLTKCSA
     LFHDLEDHAL LVDSLIQAIY RLSRALSLTR AQRDTTEDCL LALCSKLQPS TMQPLLQRLV
     FDVLHLSHHS KLPLKMLTSH YEQMWKYYSY SGSQDKQKLA SEGELQLSRK LFWGVFKALT
     KKKSFIPQLL SLCVQCLVAV AKALPPDYVE PGCLSQVDRI TSVDTDGYFE PHPVDTSNVS
     VPERLDFVVN KYAEHTHEKW SLEKFASGWV HGDQLCENAK VHPLLKPYRA LAEKEKDSYR
     WAIKETIKSM LAFGWTIERT KEGDAFGILA CACRVSQAGQ LSFEGASTFS PKPLDMSSIT
     LSWEQCAMAE QLAENYHNVW AKTKKLELES RGGGHSMLVP YDALTAKEKT KFREKAQEIL
     KFLLLHGYTV WRDRKSMEID FPATANCFGH IFLQHMLYYT EETQENMLKL EVIQARGQMP
     KGERAQDQQP ISAFPQVVLP LLEQYVKSHR LYFLSSSLKS SENRSHASKR EKEMVLCLFC
     KLAALVRHRI SLIGDEASAV TSCLRILAQA LDARILTAAA SESLQTSLHS FFEAAAADLE
     MTVGKISETL PHSRGQLSKG VVNTLNYTTS ILIPTLTSLF HHLANQNYGV DVLVGGIQVS
     CYKILNSLYS LGTSKSFYME GQRSAAGACV AALTGAFPVC FLEPTLDHSN PHSIYNVMSP
     TEIKDQGLPD RMENACRPLP SLGEALEKVE ELAGAGSVAH QMQYIHVAEV TLPMLCSYIS
     HWCRWGPEGH PEGPVLSSVV AQHASDLIGH ILRIIHNHVG ASQGDWMKQL AVFSQPIVCK
     ADSELLRSHF LPLMEKLKKR AECVQSEEEV MKAEDCCTSE AELQIQEKYR VLVQDLYAFY
     PLLIQFVDFN RARWLKETIP EAEQLFSMVA EVFVFWAKSH HFKWEEQSYV VQNRINNLAF
     LLSSNNLLEC KTETYVFSLH DVQFDHKNKG MKRKGDRYSA HTSLIVAAIK KMVPVGLRVC
     FPCDQNLIML VKNCYSQNNL EDEIREQILR YLKHFFGQSI SKAVCYKIII LIISTTQLEA
     PADTQRTVDR VLQIARVLYY LDQVEHPQRS KKPAWKNVLS KRRKRAVVAC LRMTPLYNLP
     RHRAVNLFLQ GYNRSWISTE GNDLVEMLVE DLAEGEKGEV KEVEEGAKAI DPLLQLIMLF
     SRSALTESSN LDNDNLYKDY AAIMAKSCRR ESHDDAEQEV ESFEEKEMEK QKLLYQQARL
     HCRGASEMVL QAISASNGTM GFMIGPTLKL GIALLNGGNA TVQQKMLDYL REKRNVGFFQ
     SMAGLMRSCS VLDLNAFERQ NKAEGLGMAT DESSDFAAIF SFKGEKVMPD KDLTCDLLRF
     LQLLCEGHNS DFQNYLRTQT GNNTTVNIVI STVDYLLRVQ ESISDFYWYY SGKDVIDPLG
     QHNFSKAIEV AKQVFNTLTE YIQGPCIGNQ QSLAHSRLWD AVVGFLHVFA HMQMKLSQDS
     RQIKLLKELM DLLKDMVVFL LSMLEVAGNV INGTIGKQMV DMLVESSSNV EMVLKFFDMF
     LKLKDLTSSE GFREYDSDCK GSICRKDFQK AMENCKYFSQ AEIHFLLSCI ETNDGEILEY
     QTFVDRFHEP AKDIGFSIAV LLTNLSEHMP KESRLKTFTE LAECALTYFQ PSLGRIEILG
     SGKRFERVYF EISEYSRTQW EKPQVKESKR QFIFDVVNKG GDKEKMEMFV NFCEDTIFEM
     QLAAQISGSN SGEKCNGKTE VETRELEEYS PPDCKRWTLI YYWWLMLTCA LSVKNLKTLM
     KTTPKDFLLA AVRFIRFICA LQIRCISAVI CRIMYLLYIT FVNSGLIEAA KRMKVSDLLG
     GILEPTLDEV TEVSSNVDQK ELREIGQMAS LTFPKEVDIL SDIFGLKLKK EGDQYRLVTQ
     DLSDSLTHLF SSTSRTIIDT DVCEEHHTLQ FTDYLDKEKT QDKKKENLQE KENVFRWKKT
     EKERRNAKEE TKHGAKRGCN GSKEPQRQHS ALWETISSHS KSLLNYFARN FYNMRLLALF
     VAFAINFILL FYKVAFLPAS KEQQATTSAH GKEQLSAKTN ASNGRVYFVL EESSGYMELC
     LHFLSIAHTI ISFCCIIGYY CLKVPLVIFK REKEVARKLE FDGLYVTRQP PEEDVKGQWD
     RLVINTLSFP SNYWDKFVKR KVMDKYGEFY GRKKISELLG LDQAALDFST ERKEKKLRRD
     SAWSVLFNSL DAKYQVWKLG VVFTDNSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK
     TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVIAFNFFRK FYNHSRGKET EDMKCNDMLT
     CYMFHMYVGV RAGGGIGDEI EDPAGDEFEV ERIVFDITFF FFVIVILLAI IQGLIIDAFG
     ELRDQQEQVK EDMETKCFIC GIGSEYFDKI PHGFETHTLQ EHNLANYLFF LMHLINKDET
     EHTGQESYVW KMYQERCWEF FPVGDCFRKQ HEDQLG
//
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