ID A0A087YKX3_POEFO Unreviewed; 883 AA.
AC A0A087YKX3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Metabotropic glutamate receptor 3 {ECO:0000256|ARBA:ARBA00020281};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018676.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000018676.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for glutamate. Ligand binding
CC causes a conformation change that triggers signaling via guanine
CC nucleotide-binding proteins (G proteins) and modulates the activity of
CC down-stream effectors. Signaling inhibits adenylate cyclase activity.
CC {ECO:0000256|ARBA:ARBA00025645}.
CC -!- SUBUNIT: Interacts with TAMALIN. {ECO:0000256|ARBA:ARBA00011150}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYCK01001934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007545733.1; XM_007545671.2.
DR RefSeq; XP_016523649.1; XM_016668163.1.
DR RefSeq; XP_016523650.1; XM_016668164.1.
DR RefSeq; XP_016523651.1; XM_016668165.1.
DR RefSeq; XP_016523652.1; XM_016668166.1.
DR RefSeq; XP_016523653.1; XM_016668167.1.
DR AlphaFoldDB; A0A087YKX3; -.
DR STRING; 48698.ENSPFOP00000018676; -.
DR Ensembl; ENSPFOT00000018698.2; ENSPFOP00000018676.2; ENSPFOG00000018558.2.
DR GeneID; 103133774; -.
DR KEGG; pfor:103133774; -.
DR CTD; 2913; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234595; -.
DR OMA; ILKCNIQ; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15284; 7tmC_mGluR_group2; 1.
DR CDD; cd06375; PBP1_mGluR_groupII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001234; GPCR_3_mGluR3.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF160; METABOTROPIC GLUTAMATE RECEPTOR 3; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01053; MTABOTROPC3R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..883
FT /note="Metabotropic glutamate receptor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001834688"
FT TRANSMEM 575..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 576..844
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 883 AA; 98322 MW; 127932F6AE8CFB96 CRC64;
MVSHLPSLVF VMMCQGALLA EPPLSRREIR IEGDLVLGGL FPVHEKGAGM EECGRVNEDR
GIQRLEAMLF AIDRINMDST VLPGVSLGVH ILDTCSRDTY ALEQALEFVR ASLTKVDDTE
FICPDGSYAL QDENPLAIAG VIGGSYSSVS IQVANLLRLF QIPQISYAST SAKLSDKTRY
DYFARTVPPD FYQAKAMAEI LRFFNWTYVS TVASEGDYGE TGIEAFEQEA RMRNICIATS
EKVGRSNAKK SYEAVIRQLF QKPNAHVAVL FLRSDDAREL IAAAARLNTS FIWVASDGWG
AQESIVKGNE ITAEGAITLE LAANPIPDFN RYFLSLDPVK NHRNPWFRDF WEQRFQCSLG
AGGLGLGGTP LPPCDKNLSV DQRYFEPESK IMFVVNAVYA MAHALHNMQR SLCLNTTKLC
DSMKALDGRR LYRDYILNVS FTAPFSPPGS ETVVKFDSQG DGMGRYNIFS YQRSGERYGY
VPVGEWAESL SLNNDLIRWP KEVLPTSQCS DPCERNEMKK MQAGEYCCWI CTACEPHEYL
ADEFTCSPCA PGQWPTDDLT SCYDLPEDYI MWEDAWAIGP ITIACVGFVC TGLVVWVFVR
HNNTPLVKAS GRELCYILLS GVFMCYAMTF LFLAKPSPAI CALRRLGLGT SFAVCYAALL
TKTNRIARIF NGVKDGAGTV RPRFISPSSQ VFICLSMISV QLVMVSVWLL LEVPGTRRFT
LPERRQTVIL KCNVRDSSML LSLGYDVLLV ILCTVYAFKT RKCPENFNEA KFIGFTMYTT
CIIWLAFLPI FYVTSSDYRV QTTTMCISVS LSGFVVLGCM FAPKVNIIMF QPQKNVTSHH
LNLNRFSVSG AATTYASHAS VSAHFVPTVC NGREIVDSTT SSL
//
