ID A0A087YM63_POEFO Unreviewed; 1143 AA.
AC A0A087YM63;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 3b {ECO:0000313|Ensembl:ENSPFOP00000019116.2};
GN Name=IQSEC3 {ECO:0000313|Ensembl:ENSPFOP00000019116.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000019116.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000019116.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; AYCK01001940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01001941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A087YM63; -.
DR STRING; 48698.ENSPFOP00000019116; -.
DR Ensembl; ENSPFOT00000019138.2; ENSPFOP00000019116.2; ENSPFOG00000018979.2.
DR eggNOG; KOG0931; Eukaryota.
DR GeneTree; ENSGT00940000155908; -.
DR OMA; GITMMSP; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF318; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 610..803
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 51..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 286..313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 934..961
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 51..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1124
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 126256 MW; 5E7D8A95782AA525 CRC64;
MSSSLLENPV QAILYLRELT TIVQNQQSLI QTQRARIEEL DRRVDELIGE NRHLRDHHSH
HTLPDPSCLH HHHHPQDPQL KSTTGALPEH AATPAQVEVS PGVQPPPAQP MDPGDMHRGQ
VFRNRPKLHG TALNLPPTPH AEKLTTQGVK QVPQETKPQK CMYVCVFLMQ TDGASTNEKG
QLKRRNRSET VLHQFCCPAP EHPETDTSGS SRRKCAQCPY HHRDSCLARC INSSGLALKP
SNYIVKAEFY HFPFEQNLCC GQILSLEDGT SSGGGQEVKG LKREGPSEYE INLENKNKQI
EELEQKYGGH LIARRAARRI QTAFRQYQLS KNFQKIRNSL SESKLPRRIS LRHPSPSSRS
RNAAQRHSYT LHPGGGQIPL RSKTPPPPPC RSTSLPPTSG PTLTQLEDCF SEQLHSLAQS
IDDALRGWSL SEGGEGKGLL MDPGALRAAA ESAGLPRSAS SLLMAFRDVT VHIDSNSSYT
ISSATTTTTT SLGNASGGES GSRKPSVSGT GGGGDGQSME EPEFPAPPPS EELEMVDPGS
RRGSAAPAAA GVGMEGENSS DRLGSSTSTS TSTSISTSVP GGPSPDSLQA LVVSLPRDRC
QDPASCRSPT LSTDTHRKRL YRIGLNLFNV NPERGIHFLI TRGFVPDTAI GVAHFLLQRK
GLSRQMIGEF LGNSKLQFNR DVLDCVVDEM DFSGMELDEA LRKFQAHVRV QGEAQKVERL
IEAFSQRYCM CNPDVVQQFH NPDTIFILAF AVVLLNTDMY SPNIKPHRKM GLDDFIRNLR
GVDDGADIPR EMVAGIYERI QQRELRSNED HVTYVSRVEQ SILGLKTVLA VPHRRLVCCC
RLFEVPDANK PHKQKLSALQ REVFLFNDLL LILKLCPKKK SSASYTFCKA MGLLGMQFHL
FSNEYYAHGI TMMSPFTSEK KQLVSFCSPS GEELRKFAEE LREAIAEVNE MEQIHIQWEL
ERQQGIQSHG LHTNGGQMDT HTGHGSPSGQ QDVYDKTGNN NTVEVSIHNR LQTYQLSQPS
IESAPLALAA PPTLLSPVQA GELRPETLIQ CQQIVKVIVV DQSGRGRMEA FLSQGPATHQ
LIQSAMSTPV RVREGDGPQP PLPPPPPPYN HPHQFCPPDS PMPFHHAMPL TRRRNSSGSR
SIV
//
