ID A0A087YME5_POEFO Unreviewed; 3000 AA.
AC A0A087YME5;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Dynein axonemal heavy chain 17 {ECO:0000313|Ensembl:ENSPFOP00000019198.2};
GN Name=DNAH17 {ECO:0000313|Ensembl:ENSPFOP00000019198.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000019198.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000019198.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AYCK01000849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 48698.ENSPFOP00000019198; -.
DR Ensembl; ENSPFOT00000019220.2; ENSPFOP00000019198.2; ENSPFOG00000019003.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154076; -.
DR OMA; ITMDAHG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 2..216
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 350..676
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 834..951
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 1170..1265
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1314..1587
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1600..1923
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1949..2168
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2409..2529
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2561..2685
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 2724..2998
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 2688..2729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1592..1643
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1807..1871
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2158..2188
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2689..2729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3000 AA; 342222 MW; A8C0F239C7704DF1 CRC64;
MSSKYIAHFL DEVSTWQSKL SVADSVISIW FEVQRTWTHL ESIFIGSEDI RSQLPEDSKR
FEGIDADFKE LANSVRQTPN VVEATNKPGL FGKLEDIQSR LSLCEKALAE YLDTKRLAFP
RFYFISSADL LDILSNGTNP HQVQKHLSKL FDNMAKMQFE ADKEGNPSKA AVGMYSKEDE
YVPFNQACDC SGQVEIWLNR VLDTMRSTVR HEMTEAVAAY EDKPREQWLF DYPAQVALTC
TQIWWTSDVN MAFARLEEGY DNSMKEYYRK QVSQLNALIS MLIGQLTPGD RQKVMTICTI
DVHARDVVAK MISQKVENSQ AFVWLSQLRH RWDERDRHCF ANICDAQFLY SYEYLGNTPR
LVITPLTDRC YITLTQSLHL TMSGAPAGPA GTGKTETTKD LGRALGVMVY VFNCSEQMDY
KSCGNIYKGL AQTGAWGCFD EFNRISVEVL SVVAVQVKSI QDAIRYKKQR FNFMGEEVNL
CPSVGIFITM NPGYAGRTEL PENLKALFRP CAMVVPDFEL ICEIMLMAEG FVNARILARK
FITLYTLCKE LLSKQDHYDW GLRAIKSVLV VAGSLKRGDP ARAEDQVLMR ALRDFNIPKI
VTEDMPVFLG LIGDLFPSLE VPRKTDLDFE KHVKQSILDL KLQPDDSFVL KVVQLEELLA
VRHSVFVVGS AGTGKSQVMR SLQRTYQNTK RRPVWADLNP KAVTNDELFG IINPATREWK
DGLFSSVMRE LANISHSGPK WIVLDGDIDP MWIESLNTVM DDNKVLTLAS NERIPLNPTM
RLVFEISHLR TATPATVSRA GILYINPADL GWSPQVSSWI DKREVQSEKA NLTILFDKYL
PSCLEVLKSR FKKIIPIPEQ SLVQMLCYLL ECLLTPENTP PDSSKDIYEL YFVFAAIWAF
GGALFQDQLV DYRVEFSKWW VAEFKTIKFP SQGTVFDYYI DPESKKFEPW SKMVTKFEMD
PDVPLQACLV PTTETVRVRY FMDRLLEHSR PVMVVGNAGT GKSVLIGDKL ESLDAEKYMV
RNVPFNYYTT SAMLQAVLEK PLEKKAGRNY GPPGSRRLIY FIDDMNMPEV DAYGTVQPHT
LIRQHMDYKH WYDRHKLLLK EIHNVQYVSC MNPTAGSFTI NPRLQQRHFC VFALSFPGAE
ALSTIYSSIL SQHLRGEGFG SALQKSSSTL VQLALALHQR VSSTFLPTAV KFHYVFNLRD
LSNIFQGILF STGECMKSPA DLLKIYLHES SRVYRDKLVE EQDIQAFDKL QTDTLKKFYE
DVEEEPQRTR EMNLYCHFAR GPGEPRYMSV ESWSSLSKIL LDVLDSYNEV NATLNLVLFE
DAMAHICRIN RILESPRGNA LLVGVGGSGK QSLTRLAAFI SNLEVFQITL RKSYSLADLK
TDLASLYIKA GVKNVGTVFL MTDGQVADEK FLVLVNDLLA SGEIPDLFPD DEVENIIGSM
RPEVRSLGLM DTRENCWKFF IDRVRRQLKV ALCFSPVGSK LRDRSRKFPA VVNCTAIDWF
HEWPREALES VSFRFLQEVE NIEVRETPGS PSENITQPQV KESVSRFMAY VHTSVNQTSK
EYLANERRYN YTTPKSFLEQ IKLYRSLLGQ KSKDLTAKME RLENGLQKLS STSAQVDDLK
AKLAAQEVEL KQKNEDTDKL IQEVGIETEK VTKEKAVADE EEQKVAAIAV VVSGKQRDCE
EDLAKAEPAL QAAQDALNTL NKFHRKSRSK LSVANLTAAL IMSLLKVRIN KLSDDTRQSA
ETLSNSAAHY KLVQHWSWKK ENYQAHLTFS YLVASKSYAA AGLCSWVLNI VKFYEVYCEV
DPKRQALRKA NAELAAAQEK LTAIKRKINK VLVLMLQIVA VILEEHLNEN LAKLTAKFEK
ATADKVKCQR EAESTARTIS LANRLERTLC GDVLLITAFI SYLGYFTKRY RRHLMENCWR
PFLRNQVPIP VTADLVPLTM LTDDADIAAW QNEGLPADGM STENATILTS CQRWPLMVDP
QLQGIKWIKN RYGDQLRVIR FEQRGYLDAV ERALAAGDVV VIENLGETLD PVLGPLLGRE
TIKKGSLMSE KCLLLSYKYN LKYHFSQIRY WLIVCFSPSW DLEHVILTTQ RHNQFLKSEM
NLLSCQASPG RLVIIDSDLT KEQNGFKITL KTLEDNLLSR LSSASGNFLG DTELVENLET
TKRTAAEIEQ KVKEAKVTEA KINEAREHYR PAAARASLLY FIMNDLNKIH PMYQFSLKAF
GVVFQKAVLK ADPDETLRQR VSNLIDSITF SAFQYTTRGL FECDKLTYTA QLVFQILLMN
NEISPTELDF LLRYPVQPGV TSPVDFLSSH SWGGIKSLCS MDEFKHLDRD IQGSPKRWKK
FVESECPEKE KFPQDWKSKT SLQRLCMMRT LRPDRMTYAV RDFVDEKLGG EYVMGRPLDF
AVSFEESSPA TPMFFILSPG VDPLKDVEKH GKKMGYTFDN NNFHNVSLGQ GQEVIAEQAL
DLAAREGHWV ILQNIHLVAR WLGTLEKLLE QYAEGSHENF RVFVSAEPSS TRDSHFIPQG
ILENSIKITN EPPTGMHANL HKALDNFNQE SLDMCARENE FKSIWFSLCY FHAVVAERRK
FGPQGWNRSY PFNTGDLTIS INVLYNYLEA NLKVPYDDLR YLFGEIMYGG HITDDWDRHL
CRTYLEEFIK PEMMEGEFFL APGFPLPGNM DYNSYHQFRS IVALPVRPSS QRRDRRPHAD
VREAFPHHAG DAAQRRRSRR GRRNDERGEA HQISVRSVLE DILERLPEQF DMAELLGKAE
ERTPYQVVAL QECERMNVLT QEIRLSLNAL NLGLKGELTM TSEMENLQNA IFLDAVPDSW
AGRAYPSTAG LALWFNDLLA RVKELEAWSA DFILPPAVWL AGFFNPQSFL TAIMQAMARR
NEWPLDSMCL QCDVTKKNRE DFSSPPREGA YVHGLFMEGA RWDSQTGLVV DARLKELTPA
MPVIFIRAVP VDKQESRNVY HCPVYKTRQR GPTYVWTFNL RTKEKPSKWT LAGVALLLQT
//
