ID A0A088F408_9SPHI Unreviewed; 803 AA.
AC A0A088F408;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Tyrosine protein kinase {ECO:0000313|EMBL:AIM39143.1};
GN ORFNames=KO02_22515 {ECO:0000313|EMBL:AIM39143.1};
OS Sphingobacterium sp. ML3W.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Sphingobacterium.
OX NCBI_TaxID=1538644 {ECO:0000313|EMBL:AIM39143.1, ECO:0000313|Proteomes:UP000028992};
RN [1] {ECO:0000313|EMBL:AIM39143.1, ECO:0000313|Proteomes:UP000028992}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ML3W {ECO:0000313|EMBL:AIM39143.1};
RX PubMed=25614576;
RA Smith S.A., Krasucki S.P., McDowell J.V., Balke V.L.;
RT "Complete Genome Sequence of Sphingobacterium sp. Strain ML3W, Isolated
RT from Wings of Myotis lucifugus Infected with White Nose Syndrome.";
RL Genome Announc. 3:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; CP009278; AIM39143.1; -; Genomic_DNA.
DR RefSeq; WP_038701655.1; NZ_CP009278.1.
DR AlphaFoldDB; A0A088F408; -.
DR STRING; 1538644.KO02_22515; -.
DR KEGG; sht:KO02_22515; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR HOGENOM; CLU_009912_6_0_10; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000028992; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AIM39143.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028992};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..114
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 447..519
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 584..720
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 803 AA; 90274 MW; 05B12DF68BB04431 CRC64;
MMEQQPLQQR DNQREEINLR QLFEQYAYYW RWFVFAILLS VGIAVIYLRY AQKTYNTTAK
ILLKDERSGS AGELAGIAEL SSSLGLGGGR SSSFVTDQIE VLKSRRLIKK VVDQHHLNIM
YASKGKIRST EILETDMPFI LQPQGSQDTI LLHIEVQLKD KQQLQITDLS TGKKLNASFN
KLVQIGNDSV IFRKSNNSIA DKKSGFEITV MPKDWAVDAT LGAINITPGK EMQSYMVNFT
MVSTLRKKSN LILNSLIDIY NADLTNDKMR MTRATSDFIN KRLMLISKDL SGADEEAADF
KSANSMVDMA TEAGVFLQNA SENDKRVLEY RTQLQLVDHM SDFLKGEKDG KLLPSNIGLQ
DASIGLAIEG YNKLVLERDD LLKSASDLNP TVVALNENIN ESKNNIRRSL ENYQQVTKLA
LNSSERKSNE IKGRINSIPN QEQGFKKISR QQQIVESLYL LLLQKREESE VKAAATPDNL
KIIDAAYGNG YPVSPKRSLV IFGALIVGFL IPFFILYLKF LLDNKIHSRK DIEDVVKAPV
LGEIPSSEDT IIHQNDRSSL AEAFRILRTN MNFMFGADKK DESKVIFVTS TTSGEGKSFV
TTNLAQILSM SGKRVLLIGA DIRSPKVLDY LGLSHLQHTN VGITQFLINP DMDVDNIIIK
KPGNYDFDVV YSGYIAPNPA ELLMNGHFDD VIKYAREHYD YILVDTAPVS LVTDTLLIAQ
NADLTLFVSR VNYLDKRLLQ VPRELYVDGK LKNLASVVND VDFARGYGYG YGYGYGYGYG
DKNEKKAGIA KLWQNLKSKF GFK
//
