ID A0A088FWM1_9CAUD Unreviewed; 839 AA.
AC A0A088FWM1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Putative DNA polymerase {ECO:0000313|EMBL:AIM51242.1};
GN ORFNames=phD2B_0015 {ECO:0000313|EMBL:AIM51242.1};
OS Lelliottia phage phD2B.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Autographiviridae; Molineuxvirinae; Tuodvirus; Tuodvirus phD2B.
OX NCBI_TaxID=1542498 {ECO:0000313|EMBL:AIM51242.1, ECO:0000313|Proteomes:UP000029353};
RN [1] {ECO:0000313|EMBL:AIM51242.1, ECO:0000313|Proteomes:UP000029353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Nowicki G., Barylski J., Kujawa N., Gozdzicka-Jozefiak A.;
RT "Complete Genome of Lelliottia podophage phD2B.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KM370384; AIM51242.1; -; Genomic_DNA.
DR RefSeq; YP_009102761.1; NC_025450.1.
DR GeneID; 22111945; -.
DR KEGG; vg:22111945; -.
DR OrthoDB; 3561at10239; -.
DR Proteomes; UP000029353; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.370; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00023109};
KW Reference proteome {ECO:0000313|Proteomes:UP000029353};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 556..750
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 839 AA; 95372 MW; 8FB20C3D2714EB35 CRC64;
MKNDHTHWAE FAKGRILVMD AESKGLLPQI RYNKGNHDVH IFCVMDLITT EEFLFFNAYD
DRDPDARERL IEWEGHQDGT LEDGVKFLMG ADAIVSQNFL GYDGLLLEKA FPEIWKGYNY
TEKRGKGSFR PDLAPVKVMD TLVMSRLLNP DRRLPPQAYA KGMGNVGPHS IEAHGIRIGR
YKPENEDWSK LTDHMVHRVR EDVAIGRDMF LWLLNGEWKE HQQRGVNTRT GHGIVTAYHM
EAIVALEMQR QANRGFRLDI DKSIARCEEL DEQIDKTVAG FRPHMPMRIK SKPFKPAEKQ
EYVDAANTFS LQNKIGVTLG CDCFLHAERR SDRKTVWAVT TKSGDWSANV KKDYPHLRGN
ANDTPTIKHI GPYTPVAFED IPLGNRDTVK QVIYQYGWKG VEYNDTEQAH IDEHGIPPKL
WSGKINEKSI DLWKERTASE GKSVPEWCLG IASWYILVSR RGQILNRGDV ETFLEKGHWP
SQAGTRKCRG LVPCAFSKEL GITAQEFYET YGKWPTSDVD TSEWRVPAIA ISIGTSTFRM
RHRNVVNIPA RGLYPLRDLF IAGKGKMILG CDGAGLELRV LSHFMNDPEY QEIVLHGDIH
THNQLKAGLP KRDMAKTFIY AFLYGSGIPN LAAVCGISEK EMKEVVARFE IELPSLARLK
ASVSNAGNQY GYLQAPDGHW GRIRMANGEL KEHTMLNVLL QMTGSLCMKY AAVRAFFMMR
KEKVGLDDEG HPASVANVHD ELQMEVNADE VLEVSYVLES SEWDAEEKKA YIDAEGRMWS
APVIIAGNRK EDKVVTVQRR YHRVGQIIAE AMTWAGTFLK MRCPMQGEYK IGASWKETH
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