ID A0A088SYZ6_9BACT Unreviewed; 281 AA.
AC A0A088SYZ6;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=peptide chain release factor N(5)-glutamine methyltransferase {ECO:0000256|ARBA:ARBA00012771};
DE EC=2.1.1.297 {ECO:0000256|ARBA:ARBA00012771};
GN Name=prmC_1 {ECO:0000313|EMBL:AIO18010.1};
GN ORFNames=KQ51_00106 {ECO:0000313|EMBL:AIO18010.1};
OS Candidatus Izimaplasma bacterium HR1.
OC Bacteria; Mycoplasmatota; Candidatus Izimaplasma.
OX NCBI_TaxID=1541959 {ECO:0000313|EMBL:AIO18010.1, ECO:0000313|Proteomes:UP000029408};
RN [1] {ECO:0000313|Proteomes:UP000029408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR1 {ECO:0000313|Proteomes:UP000029408};
RA Skennerton C.T., Haroon M.F., Tyson G.W., Orphan V.J.;
RT "Phylogenomic Analysis of Candidatus Izimaplasma species: Representatives
RT from a Novel Mollicute Clade found in Ocean Sediments.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AIO18010.1, ECO:0000313|Proteomes:UP000029408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR1 {ECO:0000313|EMBL:AIO18010.1,
RC ECO:0000313|Proteomes:UP000029408};
RX PubMed=27058507; DOI=10.1038/ismej.2016.55;
RA Skennerton C.T., Haroon M.F., Briegel A., Shi J., Jensen G.J., Tyson G.W.,
RA Orphan V.J.;
RT "Phylogenomic analysis of Candidatus 'Izimaplasma' species: free-living
RT representatives from a Tenericutes clade found in methane seeps.";
RL ISME J. 10:2679-2692(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:61891; EC=2.1.1.297;
CC Evidence={ECO:0000256|ARBA:ARBA00000932};
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DR EMBL; CP009415; AIO18010.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A088SYZ6; -.
DR STRING; 1541959.KQ51_00106; -.
DR KEGG; mbj:KQ51_00106; -.
DR PATRIC; fig|1541959.3.peg.100; -.
DR eggNOG; COG2890; Bacteria.
DR HOGENOM; CLU_018398_3_2_14; -.
DR OrthoDB; 9800643at2; -.
DR Proteomes; UP000029408; Chromosome.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0102559; F:protein-(glutamine-N5) methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004556; HemK-like.
DR InterPro; IPR040758; PrmC_N.
DR InterPro; IPR019874; Release_fac_Glu-N5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR NCBIfam; TIGR00536; hemK_fam; 1.
DR NCBIfam; TIGR03534; RF_mod_PrmC; 1.
DR PANTHER; PTHR18895; HEMK METHYLTRANSFERASE; 1.
DR PANTHER; PTHR18895:SF74; MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF05175; MTS; 1.
DR Pfam; PF17827; PrmC_N; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AIO18010.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000029408};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AIO18010.1}.
FT DOMAIN 21..75
FT /note="Release factor glutamine methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17827"
FT DOMAIN 117..194
FT /note="Methyltransferase small"
FT /evidence="ECO:0000259|Pfam:PF05175"
SQ SEQUENCE 281 AA; 32079 MW; 6F41BB10388FB099 CRC64;
MPTYKEALNI NEKYAIDNNK EDSAIKRLLL HFSNMESSDL ILSLSEEMPT ELYDNFLYGV
DRYITQNIPV QHIIGYEYFF GYKFIVNSEV LIPRFETEEL VANVLEQYDN VFNGEPVKVV
DIGTGSGCLA VTLSAEEQLM DVTATDISET ALEVARANNE NLGGRVKFFS GDLYEPLKDQ
KFDILVSNPP YIPNDEYVEG LVKDNEPHVA LFGGKDGLDF YRKIIEGAES ILNDKYIIAF
EHAYDKAKEL KKIINKNIKD VEIIQKKDMQ GKDRMTFVIK K
//
