ID A0A089HUH5_PAEDU Unreviewed; 343 AA.
AC A0A089HUH5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=PDUR_20315 {ECO:0000313|EMBL:AIQ13998.1};
OS Paenibacillus durus (Paenibacillus azotofixans).
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=44251 {ECO:0000313|EMBL:AIQ13998.1, ECO:0000313|Proteomes:UP000029409};
RN [1] {ECO:0000313|EMBL:AIQ13998.1, ECO:0000313|Proteomes:UP000029409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1735 {ECO:0000313|EMBL:AIQ13998.1,
RC ECO:0000313|Proteomes:UP000029409};
RA den Bakker H.C., Tsai Y.-C., Martin N., Korlach J., Wiedmann M.;
RT "Comparative genomics of the Paenibacillus odorifer group.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP009288; AIQ13998.1; -; Genomic_DNA.
DR RefSeq; WP_042207792.1; NZ_CP009288.1.
DR AlphaFoldDB; A0A089HUH5; -.
DR STRING; 44251.PDUR_20315; -.
DR KEGG; pdu:PDUR_20315; -.
DR eggNOG; COG1420; Bacteria.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000029409; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000029409};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 1..72
FT /note="Winged helix-turn-helix transcription repressor HrcA
FT DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF03444"
FT DOMAIN 104..323
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 343 AA; 38395 MW; 542AD3CB67C0C16B CRC64;
MLTERQRMIL NAIVDDYIRS AEPVGSRSIS KRGDVKYSPA TIRNEMADLE ELGFLEQPHT
SAGRIPSHKG YRYYVDHLVP WNPAGSTETE TIRAFFAEKL NAMEQLIQHA AMILSNMTNY
TSILLGPEVF HTSLRHFQLL PLDDRTAVAI IVTSTGQVEN RKVSIPPEIS VSEMEKVVNL
LNSKLVNVPL YKLKSRLYSE LGQEMQRHIS HYEELMQMLD TALESDSEQR VYLSGATNML
TQPEFRDVDK VKDILDLLEE TPTLLKMLAP AVGGTGIKVR IGTENKHEAF ADCSLITATY
SIDGEAVGSI GILGPTRMEY AKVLGILGVL SRDLTAMLGH WYK
//
