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Database: UniProt
Entry: A0A089HUM7_PAEDU
LinkDB: A0A089HUM7_PAEDU
Original site: A0A089HUM7_PAEDU 
ID   A0A089HUM7_PAEDU        Unreviewed;       295 AA.
AC   A0A089HUM7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-DEC-2019, entry version 22.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=PDUR_20745 {ECO:0000313|EMBL:AIQ14068.1};
OS   Paenibacillus durus (Paenibacillus azotofixans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=44251 {ECO:0000313|EMBL:AIQ14068.1, ECO:0000313|Proteomes:UP000029409};
RN   [1] {ECO:0000313|EMBL:AIQ14068.1, ECO:0000313|Proteomes:UP000029409}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1735 {ECO:0000313|EMBL:AIQ14068.1,
RC   ECO:0000313|Proteomes:UP000029409};
RA   den Bakker H.C., Tsai Y.-C., Martin N., Korlach J., Wiedmann M.;
RT   "Comparative genomics of the Paenibacillus odorifer group.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC         Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP009288; AIQ14068.1; -; Genomic_DNA.
DR   RefSeq; WP_042207869.1; NZ_CP009288.1.
DR   STRING; 44251.PDUR_20745; -.
DR   EnsemblBacteria; AIQ14068; AIQ14068; PDUR_20745.
DR   KEGG; pdu:PDUR_20745; -.
DR   KO; K04518; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000029409; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN          2..190
FT                   /note="Prephenate dehydratase"
FT                   /evidence="ECO:0000259|PROSITE:PS51171"
FT   DOMAIN          206..283
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   SITE            183
FT                   /note="Essential for prephenate dehydratase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ   SEQUENCE   295 AA;  32511 MW;  9430C2C125CFED26 CRC64;
     MKSIAVLPQG TTSHEALLYL MKGEPCRPVF YKLISDVFLA TAKGETDYSV IPVENTIEGS
     VSMHMDWLIH EVDLPMQAEW IYPSVQNLIA NPGEFADGKG GVDYSRIVKI LSHPVAMAQC
     GHFIRRHAPT AELETVGSTS EAVEIVKNNP GKGWAAIGIE LGAKTFGLEI VASKITDHHN
     NFTRFVLAGP GKLEIPRVST GSKTSVLITL PEDFPGALHQ VLSAFAWRKL NLSRIESRPT
     KKKLGTYYFY IDVLEPLESV LLPAAIEEIK ALGCQVRILG SYPTYTYEEE KAEVQ
//
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