ID A0A089JPC8_9BACL Unreviewed; 390 AA.
AC A0A089JPC8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:AIQ22839.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:AIQ22839.1};
GN ORFNames=H70737_08225 {ECO:0000313|EMBL:AIQ22839.1};
OS Paenibacillus sp. FSL H7-0737.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1536775 {ECO:0000313|EMBL:AIQ22839.1, ECO:0000313|Proteomes:UP000029519};
RN [1] {ECO:0000313|EMBL:AIQ22839.1, ECO:0000313|Proteomes:UP000029519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL H7-0737 {ECO:0000313|EMBL:AIQ22839.1,
RC ECO:0000313|Proteomes:UP000029519};
RA den Bakker H.C., Tsai Y.-C., Martin N., Korlach J., Wiedmann M.;
RT "Comparative genomics of the Paenibacillus odorifer group.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP009279; AIQ22839.1; -; Genomic_DNA.
DR RefSeq; WP_042186212.1; NZ_CP009279.1.
DR AlphaFoldDB; A0A089JPC8; -.
DR KEGG; paej:H70737_08225; -.
DR eggNOG; COG0626; Bacteria.
DR HOGENOM; CLU_018986_2_0_9; -.
DR Proteomes; UP000029519; Chromosome.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF91; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000029519};
KW Transferase {ECO:0000313|EMBL:AIQ22839.1}.
FT MOD_RES 199
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 390 AA; 42528 MW; 21E21040D9123388 CRC64;
MDDKLRIESR LAQIGSQEDP ATGAINFPIY NATAFRHPKL GQSTGFDYSR TKSPTRSVLE
NAAAELESGD AGFACSSGMA AIQTVLTLFA QGDHLIVSLD LYGGTYRLLE RIMSKFGITA
SYVDTNDLDA LETSRRPNTK AVFIETPTNP LMMITDIEAV CTWARHHGLL SIVDNTLLTP
FFQRPIELGA DIVVHSATKY LGGHNDVLAG LIVSKGVELS AELAILHNSI GAVLGPTDSY
QLMRGLKTLA LRMERHESNA LAIAHYLLEH PAIAEVFHPG LPDHPGHEIQ NRQSSGNTGI
FSFKLKDARY VEPLLRHIRL IAFAESLGGV ESLMTYPAVQ THADIPVEIR NAVGVDDRLL
RFSVGIEHAE DLIADLSQAL EAARAEIESK
//
