ID A0A090CGV1_PODAN Unreviewed; 2440 AA.
AC A0A090CGV1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Signal transduction histidine-protein kinase {ECO:0000313|EMBL:CDP27381.1};
OS Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS (Pleurage anserina).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC Podospora anserina.
OX NCBI_TaxID=515849 {ECO:0000313|EMBL:CDP27381.1, ECO:0000313|Proteomes:UP000001197};
RN [1] {ECO:0000313|EMBL:CDP27381.1, ECO:0000313|Proteomes:UP000001197}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383
RC {ECO:0000313|Proteomes:UP000001197};
RX PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL Genome Biol. 9:R77.1-R77.22(2008).
RN [2] {ECO:0000313|Proteomes:UP000001197}
RP GENOME REANNOTATION.
RC STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383
RC {ECO:0000313|Proteomes:UP000001197};
RX PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA Couloux A., Wincker P., Debuchy R., Silar P.;
RT "Maintaining two mating types: Structure of the mating type locus and its
RT role in heterokaryosis in Podospora anserina.";
RL Genetics 197:421-432(2014).
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DR EMBL; FO904938; CDP27381.1; -; Genomic_DNA.
DR eggNOG; KOG0519; Eukaryota.
DR InParanoid; A0A090CGV1; -.
DR Proteomes; UP000001197; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43047:SF46; HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDP27381.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000001197};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..406
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1949..2174
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2246..2370
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 57..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2201..2238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2402..2440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2201..2224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2301
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2440 AA; 268687 MW; 3539BEDB449E8F6C CRC64;
MDTAARLLDE QLESPARLFE RLHQISGYVW DDSRPPFHST YDNWHIYGTR FVSPFSSGGA
VPTSPAPHNS PASQPGVAGF TLPPAHRPSS RDHRPSTSSQ LSEVGSERSA TSLPVIPPTG
SDVPVIEEPV VARVSYHVLR EERTFHIFKS LIAHTDSSAE RERIVKPLDI IRLPALPGDR
GAVIVTVYED PGPNYLWDVL DLGPAFYYAK KHGDGWEPSR PGHTGHKLAP PISLQHFLDF
AIGSAQSLEM IHHGQGTIHG EIRGDTFHYN VETNKVKLVC LGSGLRSFEH GLTSTGWSAL
SRELGAKHKL QYISPEQTGR MPAEPDTRTD IYSLGALFWS LLTQHPVFHG ESPLDVVQGV
LSRRIPSIST FRIDVPEVIG RIIQKCTAKN VNDRYYSASG LRHDLTWVKK LLGVGDLQAL
KDMKIGTNDV SSFFRLPSSM IGRERERAEL LKVIDRVAKR HSLALNGAAA HRQSDGSNVS
TEVDAADVSS DGASSAEGTN RFGTSVTNKD RRSSLYHSAV GVDSVGAYTE VNSSGAVRPP
RPWDRQHSVS LKESVQSAEA STSEPSWRSA AVATNGTDSS AASISRPLGP AKYRKQGQCE
IVMIEGAGGL GKTCLVQSVL VDARRMGYCA TAKFDTARRT AYGPLIKLLS SLFRQVWGER
NTDTPFHQAL KQSVRPTWPT LHKVLGLPEH MLPRLDTPLG RSSSSPQPPK SNNLRRRPSS
PEFSGASSKL GASSASSSAQ STQEFLRGGS TTKVNRLANI FLDVLRLFTR HKFICFCLDD
LHYADDESLE LITQIVSAKL QMVLIITYRP DEMSPEKLYT ITNPPKSEDH LRACYPITTK
ITLDPLSEEE IREYVSTTLS LPKDQVVSLA LVLQSKTAGN PFYMREMLSA GHRKKCIWYD
YTEGRWKFDL DRLFEHFRGE QDYDVLDTAF ITRRLGELPQ ESRSILAWAA LIGQTFSLDL
IEKLMEGEFY YTDDNQDGSD DCAILPHGKQ DIFAGLEAAI QAYIIIPGDR DDQFRFAHDR
YIQAASALRE CNSLKMHFVI ARTLLAHFPK SQENTASHIC ESIEVIKKRI SERAPFRKVL
MERAGEAVES GARPTAAKYY SNALALLQSD PWNDDAPDVS YEETLQLHRR AAECFLYMGR
PPSANMLLQT MIENARSPLD KTPAWVLQSR IFAQSGDSAQ ALTSLRQCLR AFGVNVDECP
TMKKCDEQFE KLSVKIQNMD RQDVMNPLAS SDPPPESLVS LGAVLAETTS AGWWSDCVVF
YQLALLMVET HFTKGPYPQS GMAFLHMSMI ALSRFNMVDF AQSLASICFD LLQKSSDPFS
LVRGYMIYAN FIGNIQDLTG ATVEQLEANV LAAAPLGDRV SVILSFGLLA LLKFFASQDC
AELEVYCQFA CDDIPSWHLD TKGGTLLISV RQLCRALQGK TRASQPLEVM NDDQHDASTY
KNWLNTHTNN GGRSLLLYET MEIVPLFLYG HYGRAIEIGK ACLEQAELLW SARNTRLAMF
FYGLALAGTV LREQQDPREP PKGDPKVRRD EAIRKVEELN RKIKDWKAVH NVNYLAWSKL
LDAQVSEMLG NHGIAIRQYE EALDHASEHG FVFEEALGNY LMANIFIRNA ARRSARSALR
DAVSLYRQFG ATGIADLIET EHSILLHGPA GNLRTCDAGV QTDFFGDTAS VQYRGVDTEE
SQQSTRAAVA ALKGERMMAW RGSMQPEAGA GLPALDMIDL HGILTSSQAI SSVLRVDELL
RTMCSVILQA CSGSATFAAI IVQDEGSVDW CVAASGDSEN GATAHIPGIP LSGTDLVPEN
VILYCTRLRE KVFLQDLVND ERFGNVSDQW LRKNPNSKAV IAVPIRHGNS KPLLGVLYLE
GLPGSFTDRN VTVLELLVGQ ISISYSNALS MKSVERVSAE NISMVELQKQ ALATAIEAEA
KAKNAEAEAI RNVKLAEEAT KAKSIFLANV SHELRTPLNG VIGNSELLRD SGLNREQMEM
ADSIRVSADL LLTVINDILD FSRMEADKMK LYIIAFNPEE MVREVVRAVS YSNREKTSKK
NVKIVQDINL PPMLIYGDPI RLHQVLGNLI GNSLKFTEDG SITIGARIDE ETPDKATLTF
WVKDTGIGIS QQHLENLFQP FSQADASTAR KYGGSGLGLS ICKSLIETMM EGTIQLESEE
NVGTTAWFTV TFEKAKPEVV AGDEQALANG DDGLLPVESA YRQQQSNSEN SSDSTTLTGG
FQPSSSHPPL PPAPPNLTQI PKNELRICIA EDNAINAKIA MQYMQRLGYP NVDTYENGLK
AVEGLREKAK EGRPYHIILM DVQMPVLDGY EATKLLRTDE LESVRKVLVI AMTASAIQGD
REKCLAAGMN DYLAKPVRGE VLKRKLEAYL GAGGTTPASG GPVNVASAAV GGVVGNGVEK
KKVAGGEVEG EKTVEVDGER DKTEVKGKED ERDKGGGDGH
//
