UniProt: A0A090I8C6

Database: UniProt
Entry: A0A090I8C6_9GAMM

LinkDB:  A0A090I8C6_9GAMM 
Original site:  A0A090I8C6_9GAMM

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (4)   
   InterPro (3)   
   Pfam (1)   
All databases (13)   

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ID   A0A090I8C6_9GAMM        Unreviewed;       255 AA.
AC   A0A090I8C6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00040167, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
GN   Name=hemD {ECO:0000313|EMBL:CED58085.1};
GN   ORFNames=MVIS_0043 {ECO:0000313|EMBL:CED58085.1}, NVI5450_2837
GN   {ECO:0000313|EMBL:SGZ04897.1};
OS   Moritella viscosa.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Moritellaceae; Moritella.
OX   NCBI_TaxID=80854 {ECO:0000313|EMBL:CED58085.1, ECO:0000313|Proteomes:UP000032438};
RN   [1] {ECO:0000313|Proteomes:UP000032438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hjerde E.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CED58085.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Hjerde Erik;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SGZ04897.1, ECO:0000313|Proteomes:UP000183794}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NVI 5450 {ECO:0000313|EMBL:SGZ04897.1};
RA   Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|ARBA:ARBA00037589, ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
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DR   EMBL; LN554852; CED58085.1; -; Genomic_DNA.
DR   EMBL; FPLD01000073; SGZ04897.1; -; Genomic_DNA.
DR   RefSeq; WP_045108545.1; NZ_FRDW01000053.1.
DR   STRING; 80854.MVIS_0043; -.
DR   GeneID; 61296457; -.
DR   KEGG; mvs:MVIS_0043; -.
DR   PATRIC; fig|80854.5.peg.43; -.
DR   HOGENOM; CLU_011276_9_4_6; -.
DR   OrthoDB; 9787650at2; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000032438; Chromosome complete sequence.
DR   Proteomes; UP000183794; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032438}.
FT   DOMAIN          16..242
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   255 AA;  28231 MW;  F4856B956C1398C8 CRC64;
     MKIRALITRP RVKGEQLARQ IEAANGAALC CPFIDISAGQ QFNKVSSLLE KLQPGDYIIA
     ISDNAINYAN RSLIQENKTW PQHINYIAVG PTTALRWQKY GINHAKIPQT HDSEGVLKLL
     INTAVEHKNI VILRGNGGRE TMAEDLIQRS ANVTYCEVYQ RSSPDYEPEL LINKWQQFAI
     NSVIITSGEI LGNLIKTIPY TALPWVLNLH FIVPSQRIAA LAHGLGIEHV TIASGASNNS
     LFNAVKQLDM QIGIS
//

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