ID A0A090J1I3_9BACI Unreviewed; 817 AA.
AC A0A090J1I3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=CRISPR-associated helicase Cas3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BT1A1_2684 {ECO:0000313|EMBL:CEE02478.1};
OS Caldibacillus thermoamylovorans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Caldibacillus.
OX NCBI_TaxID=35841 {ECO:0000313|EMBL:CEE02478.1, ECO:0000313|Proteomes:UP000040576};
RN [1] {ECO:0000313|EMBL:CEE02478.1, ECO:0000313|Proteomes:UP000040576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wibberg Daniel;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CCRF01000075; CEE02478.1; -; Genomic_DNA.
DR RefSeq; WP_034771998.1; NZ_CCRF01000075.1.
DR AlphaFoldDB; A0A090J1I3; -.
DR Proteomes; UP000040576; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000040576}.
FT DOMAIN 38..219
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 246..413
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 570..799
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
SQ SEQUENCE 817 AA; 93468 MW; 52B744A208111F53 CRC64;
MFLTDDKMDS LFHMMTRKLG NKHNKGFFPL GFQKQLIDAH LNKRKNVILH APTGAGKTLA
ALAPFYISKS LNGEIDFPNQ TIYILPLRTL AHSLAEEAEQ ATNQWTVKTQ TGEVQKDPFF
SDGDVVFTTI DQALSGALTI PLSLSTRLSN INAGAWVGSY LVFDEFHLLD INLAFQTTVH
LLKQLCVDMP LTRFTIMTAT LSREMRKFLA KELNAVHIEV TEEDLPQIKS QYQKKRKVIT
HSTTLNAGEV LKRHQNKTLV IVNQVDRAIS LYVDVVKRNP IDTKVFLLHG QLLSDERKDV
EKKLKEYFGK NCNRKKAILI ATQVIEVGLD ISSDVMLTEV SSGRSFLQRI GRNARFENQE
GTVHVYSINY PDNNQPWLPY EKDDVKATER YLQSYLGFSF DYARANEMMD TLYCEIDKKT
GVMLKLNEES FTSQIAEAYS THKKGLAGRL IRDIQNVSVL LHYNPPTDES LYLYETISIS
LGKMKGFVSK LNKASTAFHG KVKKIVYDKD DKLVLQNIKG VDDIHSYDFI VIHPSLATYE
KNVGLLLGKP SSDETYCFPL KNDDKIIKRY SYKMDTIEEH IRACLMAYRE RCYSKNKYAI
KAIAQLFHLS EEDIKRLIKF VIVTHDMGKL EKAWQDKALN RQLEYDPMFS LDTALAHTDN
PSGKKVHFPD HSILGAVMAY YLLQVDGKYS HMMRAILTAI AHHHSPTVTG KKYADESNSS
KSIKKAGVLL PLLSEIKWDI STDQYVSTLK KAVKIYEGEK EWKNKWSNWG AGHRSREYWL
YLFLVRQLRI SDQNSFDYIP AIRSGERLTN IGENMDE
//
