ID A0A090KZL5_STRRB Unreviewed; 556 AA.
AC A0A090KZL5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Parafibromin {ECO:0000313|EMBL:CEF62975.1, ECO:0000313|WBParaSite:SRAE_1000124100.1};
GN ORFNames=SRAE_1000124100 {ECO:0000313|EMBL:CEF62975.1,
GN ECO:0000313|WBParaSite:SRAE_1000124100.1,
GN ECO:0000313|WormBase:SRAE_1000124100};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF62975.1};
RN [1] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_1000124100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000124100.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CEF62975.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF62975.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_1000124100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC73 family.
CC {ECO:0000256|ARBA:ARBA00010427}.
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DR EMBL; LN609528; CEF62975.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090KZL5; -.
DR STRING; 34506.A0A090KZL5; -.
DR EnsemblMetazoa; SRAE_1000124100.1; SRAE_1000124100.1; WBGene00257845.
DR WBParaSite; SRAE_1000124100.1; SRAE_1000124100.1; WBGene00257845.
DR WormBase; SRAE_1000124100; SRP02956; WBGene00257845; -.
DR eggNOG; KOG3786; Eukaryota.
DR OMA; ERTCHDS; -.
DR OrthoDB; 180759at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 3.40.50.11990; RNA polymerase II accessory factor, Cdc73 C-terminal domain; 1.
DR InterPro; IPR007852; Cdc73/Parafibromin.
DR InterPro; IPR031336; CDC73_C.
DR InterPro; IPR038103; CDC73_C_sf.
DR InterPro; IPR032041; Cdc73_N.
DR PANTHER; PTHR12466; CDC73 DOMAIN PROTEIN; 1.
DR PANTHER; PTHR12466:SF8; PARAFIBROMIN; 1.
DR Pfam; PF05179; CDC73_C; 1.
DR Pfam; PF16050; CDC73_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..321
FT /note="Paf1 complex subunit Cdc73 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16050"
FT DOMAIN 392..546
FT /note="Cell division control protein 73 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05179"
FT REGION 162..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 556 AA; 63714 MW; 9EB1D8735D513DE0 CRC64;
MTEYLIQKLK DNNYQPMYED YATNYWFCII YNFLGVSFVS IYICIKGKKF VDIEFHGQTY
YIFGEFAFPK NALTRFPNSQ KKGVYYDIES LKYFWENKED NHALYVKKAI AKGGLTVIGR
PDRQSIIKYL EGEDSIIDEN DPNAPKVSPL LLTDMVNSSD FEPERKKFKS DHNGEAAMEV
DGDDLTDDKA QGNSHRSLNS DLTAEKIAIL KNKAKKHKKH MIQNNEDEDN VMEMDPSIAK
VYQRVSGARE RLDERTCHDS STFMDGTTSQ FDSFCAIFRN CIEKKKKPHS INESNNKKVV
TQPASSSQQP SGGYSRYDQE KFSKHDSLGF EINPNLTFQG TTLHSLSTAV SAKSLLSSNM
QQNSRSPGTP LSSVNRSDST NASPNGQQKR KSRTPIIIIP SSNSSLITLY NVADILQDLK
FISTSEKKDL TKIKRPNEVM IHRKKDSGDT VHYRVVDSPL GFTDEEWERV VAVFVQGPAW
QFKGWQWKGN PVDILANVLG FHLKFDCDKL DDNIKQWSVN ILDISKTRRH LDKASLLKFW
QILDRWIVKH KPNLRF
//
