ID A0A090L172_STRRB Unreviewed; 416 AA.
AC A0A090L172;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Cathepsin F {ECO:0000313|EMBL:CEF63540.1, ECO:0000313|WBParaSite:SRAE_1000180100.1};
GN ORFNames=SRAE_1000180100 {ECO:0000313|EMBL:CEF63540.1,
GN ECO:0000313|WBParaSite:SRAE_1000180100.1,
GN ECO:0000313|WormBase:SRAE_1000180100};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF63540.1};
RN [1] {ECO:0000313|EMBL:CEF63540.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF63540.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_1000180100.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000180100.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_1000180100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LN609528; CEF63540.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L172; -.
DR STRING; 34506.A0A090L172; -.
DR MEROPS; C01.A44; -.
DR EnsemblMetazoa; SRAE_1000180100.1; SRAE_1000180100.1; WBGene00258410.
DR WBParaSite; SRAE_1000180100.1; SRAE_1000180100.1; WBGene00258410.
DR WormBase; SRAE_1000180100; SRP04654; WBGene00258410; -.
DR OMA; ALKHDQC; -.
DR OrthoDB; 1085298at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF878; PROTEIN CBG15672; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..165
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 202..415
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 416 AA; 48235 MW; 5FE8E4AD994A564A CRC64;
MKKPYDTIGI PPPSNDYQDF QFKREKIYQF NVKNYDQKKS NFKLYIIFCL SVFLTTSLVV
KLIKIYSTTT IIEKSQLTSF MCDFNNKEYK ELMSHSGISN EKRKFTCDFL KFLDKFNKNY
NTINEKKSRF EHFLNNIQIV NEKNNAENDV VFKINKYADW SDDELRQLLM SDEEIKDMEN
MTLVDPFIES SFLPIESLGN DTISNFDWRE KNVVTAVKDQ GKCGSCAFFA NVAVIESANA
IKGEPLARLS EQELLDCDKK DNGCNGANRV NIFKHVQRNG IVYENYYQYK GEQKECRSMI
GKPRVYISGY KYLGRNEDNW IRYLKEKGPF SVGVQVPKQM YYYSSGVFNP TLEDCKEKSM
GSHAMAVVGY GEENGQKYWL LKNSWGQGYG IENGFIKMRR GVNSCGIANY AYGVEI
//
