ID A0A090L2C9_STRRB Unreviewed; 1735 AA.
AC A0A090L2C9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Rim {ECO:0000313|EMBL:CEF62232.1, ECO:0000313|WBParaSite:SRAE_1000050500.1};
GN ORFNames=SRAE_1000050500 {ECO:0000313|EMBL:CEF62232.1,
GN ECO:0000313|WBParaSite:SRAE_1000050500.1,
GN ECO:0000313|WormBase:SRAE_1000050500};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF62232.1};
RN [1] {ECO:0000313|EMBL:CEF62232.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000050500.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF62232.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000050500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; LN609528; CEF62232.1; -; Genomic_DNA.
DR STRING; 34506.A0A090L2C9; -.
DR EnsemblMetazoa; SRAE_1000050500.1; SRAE_1000050500.1; WBGene00257102.
DR WBParaSite; SRAE_1000050500.1; SRAE_1000050500.1; WBGene00257102.
DR WormBase; SRAE_1000050500; SRP05393; WBGene00257102; -.
DR eggNOG; KOG2060; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR eggNOG; KOG3799; Eukaryota.
DR OrthoDB; 2891597at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0030424; C:axon; IEA:EnsemblMetazoa.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0048786; C:presynaptic active zone; IEA:EnsemblMetazoa.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:EnsemblMetazoa.
DR GO; GO:0030421; P:defecation; IEA:EnsemblMetazoa.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0040011; P:locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0007626; P:locomotory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0007617; P:mating behavior; IEA:EnsemblMetazoa.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:1905909; P:regulation of dauer entry; IEA:EnsemblMetazoa.
DR GO; GO:0043051; P:regulation of nematode pharyngeal pumping; IEA:EnsemblMetazoa.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:EnsemblMetazoa.
DR GO; GO:0016082; P:synaptic vesicle priming; IEA:EnsemblMetazoa.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157:SF21; RAB3 INTERACTING MOLECULE, ISOFORM F; 1.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 6..132
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 65..120
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 700..777
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 941..1066
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1581..1711
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 149..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..58
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1225..1265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1735 AA; 194677 MW; 4B2C62B14E1FF86E CRC64;
MADPPMPDLS HLSAEERAII EQVFQRQKEE EEKEVQISQK ANQELVEIER QIQERKETAH
RLLGTQDDAI CQICQKTKFA DGIGHKCFYC QLRSCARCGG RTQSKNKPIW ACSLCQKRQS
ILAKTGKWFQ PDDVTDVERK PSDINIGLGG NTSLVKNTNT TTTSNINQGK GNGNTVKDNT
NVEMDNNQGN VNVISKENNE QNIDSTNTRN QLPHQKISIQ RQPTVEIMGN NLRPSTSMNQ
GMPQQQIHPE QMIGNQLQHQ QLNTGGHIPR QHPPQNKMQM TSSSSQIMGP QQKYHPQQSN
NPPSQQQQSQ ASIQQQPQQT SQSTATSLFG KIIGGVASGV TSAISSTAHS TILPTTTITN
NTTTIKGTTS QISSSPSQNY PSTTGIQSMG GGQQSQYQQP PGINTIYQDK INYDNKNLNQ
QYKYNISNNG RGNDTYEYHD NNTIQYNNDT NLLYQNQETN NFIESQQPPV IQTSDYHNQI
LQQNLTRKGS KKSRNLQRQY QSLSSSDEEQ FDIRTTTNDN TIGSSLPGRS PSYRNKHSKS
NFLSKTPNNI LSTDISTEND ILRYIYGSDT ETAPINTKRR KSYKIFGQGM NSLSFDDDSL
YNDGNSFKSN NIFRRRRSNS IRSDKGSFPL SSNFLQSLSS PLGYDNKNDL ADKIKRYLNS
PVTWTPTADK KRLIGHMVLN KNDIINNNTS PYLTTKPFYG DLGLKVIGGH KTPIGRLGAF
ITKIKPGSVA DVIGHLRPGD EVLEWNGICL QNMIHEQVYD IINQSKNDQS IELIVSRDLI
NNPFNYINNF GNNSISQLDI NNFGGNNFSG EIKRPMSARG FLYNNTGKYS PEPYGGSSNF
ITSQGRNNMY IQDGGNLRHS QSLLSSSNYH FNKTGTLGSG GQYQNSFSPS GSVNGILPQQ
FIQTNPQDIQ MYSSNNPMLL SPYHQHHPQQ QSPTNVGVNE ITGRIEISLL YSSLDKQLIV
TIHRALDLTP RVTGGSRNPY VKLFLLPDRS EKSRRQTVVL SDSMIPVWNE TFYYQNITED
MLFGDQKRVL EVTLWDYDKY DANMFLGEVL IDFNTVPLNN EICLYNLLDM DDEHPIRMYL
RHRKGSYTNP LSTSSKIQPP RPHSEMAYYP SSGLPPPGNS GSIYHNYHYN QPNNINSIFY
DYPTGTLDMN KRSRNPISIN NRNSNISRSR TYDRSAYNNI IDKNKRNYYP NNIDDLMIRD
QGGGDYPIPD YDYTPPPGDK INNGYLSDTG GQMYRNSSGR SIPLYDNTGN ERTYSPKNQN
YYDNRYGKRQ GGYRNLPNPD DVPSLQQQQQ QSLTSIHNSN NDQQQTYFNE SGTSSYPPYQ
QHDGRDQQKQ YYGNQCNDIG YNNRNKNDFI YDTRTPQGRL RYEATMMQEG GGYGSDNSES
LSINSIQSLQ NNTTTTVIRR SNQGIEEYDG GSGITVIRHE PIEEADYGMM GKDEGNIRRR
DNTTNNKNQS TGNGVLPSGG SGQISSGTTS GQGKIDQNLK DRKKSIMTRL IPGRSQPSDC
PKRTGFARSE EVGVPDNLTV NGSGDRLQAP FLKQASKDST DSSHSENIMP LLPDGPLGHF
IENLGPGQVV GRQVLASPVL GEINIAISLV VNRSGTGHAI DIEIIRAKNL VTKPGSKTPP
SPYVKVYLLE GKNCIAKAKT SLSNRKTVNP LFQQHLIFNE NYKKKMIQVS VLGDYGRMER
KSFMGIALIR LDDLNLENNF RATGQPVVGW YKLFHNNSLA GTGPIRKDSE NSLMG
//
