ID A0A090L5J7_STRRB Unreviewed; 663 AA.
AC A0A090L5J7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=CNNM transmembrane domain-containing protein {ECO:0000259|PROSITE:PS51846};
GN ORFNames=SRAE_1000332400 {ECO:0000313|EMBL:CEF65071.1,
GN ECO:0000313|WBParaSite:SRAE_1000332400.1,
GN ECO:0000313|WormBase:SRAE_1000332400};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65071.1};
RN [1] {ECO:0000313|EMBL:CEF65071.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000332400.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF65071.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000332400.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ACDP family.
CC {ECO:0000256|ARBA:ARBA00010484}.
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DR EMBL; LN609528; CEF65071.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L5J7; -.
DR STRING; 34506.A0A090L5J7; -.
DR EnsemblMetazoa; SRAE_1000332400.1; SRAE_1000332400.1; WBGene00259941.
DR WBParaSite; SRAE_1000332400.1; SRAE_1000332400.1; WBGene00259941.
DR WormBase; SRAE_1000332400; SRP04999; WBGene00259941; -.
DR eggNOG; KOG2118; Eukaryota.
DR OrthoDB; 248389at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:UniProt.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR GO; GO:1905941; P:positive regulation of gonad development; IEA:UniProt.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF59; UNEXTENDED PROTEIN; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 177..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..354
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT REGION 587..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 75653 MW; 35E168AAA60F49DB CRC64;
MKCKHNKYNR KRIILKRNTD ILDTTPEISN PNNVKNNTEY DFKSNNQIPD ITISGLRLQP
KDNLTKSIDG YTNDGIPIVE SKTEIKIVVF GSNLQYVNYI GFTITDNCND MTVTVSKKKF
INVTSKSIIF VAALPDKESI YRLCYHLSTS NNKYIFIKEE NINISTKLVP KKYIMPLWIQ
ILVIIFFAVL SGLFSGLNLG LMTLSPQELE LITKSGSEQD KKYAEAVMPI RKSGNFLLCS
LLIGNVLVNS AISILMDDLT SGIVALIASS AGIVIFGEII PQSLCVKKGL AVGANTIWIT
KFFMCITFPV SYPLSKILDI FIGVEVSSYD RKKLMELIKM TTKGESAMEF KIAFGAMEIT
DKTVKDVMTK IEDVFMLSET TVLNEHKVTE IVNMGYTRIP VYANNDRNNV VNLLFIKDLA
LMDPDQNFTV KTVCSYNQHL LRFVIEDTPL KTMLEEFKKG EYHLAIVRKK TKNNNVGELC
GLVTLEDILE EILKAEIIDE TDVVIDNRDS LKRISFVVEQ ETTKEEITND NNEDNKNNNI
IFNISSEEDK SNTISYFDVS SMEEKKDLYK LRNENLKPRI LTSTPITKRV KESSSTSFPE
SQKSEDFISD RNEKNKKKTE KKLINVKKGR VSKINIEEKK EVLKRRYPLR DRKPVCRYGF
KDY
//
