ID A0A090L5T6_STRRB Unreviewed; 372 AA.
AC A0A090L5T6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN ORFNames=SRAE_1000333500 {ECO:0000313|EMBL:CEF65082.1,
GN ECO:0000313|WBParaSite:SRAE_1000333500.1,
GN ECO:0000313|WormBase:SRAE_1000333500};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65082.1};
RN [1] {ECO:0000313|EMBL:CEF65082.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000333500.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF65082.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000333500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR EMBL; LN609528; CEF65082.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L5T6; -.
DR STRING; 34506.A0A090L5T6; -.
DR EnsemblMetazoa; SRAE_1000333500.1; SRAE_1000333500.1; WBGene00259952.
DR WBParaSite; SRAE_1000333500.1; SRAE_1000333500.1; WBGene00259952.
DR WormBase; SRAE_1000333500; SRP01681; WBGene00259952; -.
DR eggNOG; KOG3988; Eukaryota.
DR OMA; LNDFRQC; -.
DR OrthoDB; 5391764at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788:SF10; PROTEIN-TYROSINE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CEF65082.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 372 AA; 42551 MW; E8C4A80EB6E31859 CRC64;
MMICPTRGKP FFLFIGVVSI LFLVSVLVKI TRNNNDDAFE RKSAHVISGT VRTEKYTFGN
ITFDNNSPFI FIGGMPRSGT TLMRSMMDAH PLVRCGEETR VIPRILSLLS QWKRSEKEWR
RLQEAGVTEE ILDVAITSFI NHIIVGHGKL AERLCNKDPF TLKSTLYLSR VYPNAKFLLM
IRDGRATIHS VITRKVTITG FDLTNYKQCL QRWNAGIELM YKQCMEVGPL KCMVVHYEKL
VLHPRSMMEK ILKFLDIPWN ETVLHHEQFI GKKISLSKVE RSSDQVVKPV NLDALSKWVG
NIPDDVVKNM AKIAPMLRVL GYDPHANPPN YGVPDPEVLK KTEDIHIHGQ EWYKKAVAVV
NDPKRVDKPI VQ
//
