ID A0A090L5X5_STRRB Unreviewed; 714 AA.
AC A0A090L5X5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=GH10531p {ECO:0000313|EMBL:CEF65117.1, ECO:0000313|WBParaSite:SRAE_1000337000.1};
GN ORFNames=SRAE_1000337000 {ECO:0000313|EMBL:CEF65117.1,
GN ECO:0000313|WBParaSite:SRAE_1000337000.1,
GN ECO:0000313|WormBase:SRAE_1000337000};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65117.1};
RN [1] {ECO:0000313|EMBL:CEF65117.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000337000.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF65117.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000337000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; LN609528; CEF65117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L5X5; -.
DR STRING; 34506.A0A090L5X5; -.
DR EnsemblMetazoa; SRAE_1000337000.1; SRAE_1000337000.1; WBGene00259987.
DR WBParaSite; SRAE_1000337000.1; SRAE_1000337000.1; WBGene00259987.
DR WormBase; SRAE_1000337000; SRP07618; WBGene00259987; -.
DR eggNOG; KOG3645; Eukaryota.
DR OrthoDB; 2872899at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19064; LGIC_TM_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945:SF784; ACETYLCHOLINE RECEPTOR SUBUNIT BETA-LIKE 1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 100..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 279..304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 77..278
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 285..681
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 714 AA; 82628 MW; 381F917F5D645946 CRC64;
MGLLINKNNY KFIFILLSFV FPILIKNQSF NFYSNPSKSS SSSSYEEIES SEEELNNNIS
FNLYNGKFQN TVTFEDEERL AIDMFKDYNR LIRPSPCNNI SVVMVEFGMA MILLINIDEK
NQIMQTNVWL TFNWNDCQFN WDPKNYGGIE SLRVANDRVW LPEIVLFNNA DGNYEVSYHS
NVVVDYKGNV QWVPPAIYKS SCTIDVEYFP MDQQICHLIF GSWTYKKDEV KLSWYMNKRS
VELSDYSPSG IWDVIDVPGQ LTDDKSRIHF QIVIRRKPLF YTVILIIPTV LMAFLSIMVF
YLPAECNEKI TLGTSILLAL VVFLLLVSKI LPPTSDTIPL MAKYLLLTFV LNILTIMTTV
IIINIYFRSE TTHQMPEYVR YIFLTLLPQI LMMQRPERIP VFNGYFVEEY NADEIFDASL
LMPSLPATML PFTNLGKTFS PLERRKKRII ENSPESSSYF KKKSLNSPNI GRINFNNFKK
YSIKKFDIKS NVRKFSNIQI GNPFIDGNQN TKENGISLKK KVSFSLADIK SLQNHGSKES
VKKISNICNS YDSDDENFNN IPIKSDIVVE MKEKEQHPSS AYSTNYINIP SKILNDNNKK
YHNNNNDNNR NKCKRSVREE IKELSGNVRE TIEGIAFIAE HMKSEMGSKK IKDDWKYIAM
VLDRLLLLIF FGITLGGTFS IIFSAPHIFE FVDQDAVIER LKLMTNERAN NLLT
//
