ID A0A090L6M0_STRRB Unreviewed; 1092 AA.
AC A0A090L6M0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Integrin alpha chain family and FG-GAP repeat and Integrin alpha beta-propellor repeat and Integrin alpha-2 domain-containing protein {ECO:0000313|EMBL:CEF65392.1};
GN ORFNames=SRAE_2000007200 {ECO:0000313|EMBL:CEF65392.1,
GN ECO:0000313|WBParaSite:SRAE_2000007200.1,
GN ECO:0000313|WormBase:SRAE_2000007200};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65392.1};
RN [1] {ECO:0000313|EMBL:CEF65392.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000007200.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF65392.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000007200.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; LN609529; CEF65392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L6M0; -.
DR STRING; 34506.A0A090L6M0; -.
DR EnsemblMetazoa; SRAE_2000007200.1; SRAE_2000007200.1; WBGene00260262.
DR WBParaSite; SRAE_2000007200.1; SRAE_2000007200.1; WBGene00260262.
DR WormBase; SRAE_2000007200; SRP07695; WBGene00260262; -.
DR OMA; HYINRTV; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 18..1092
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5015017695"
FT TRANSMEM 1038..1060
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 22..83
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 318..382
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 446..508
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 493..652
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 660..807
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 814..945
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1092 AA; 123097 MW; 6EC9BAF72A78BADA CRC64;
MRLIFILFYY LFNKIFSFNI DISSPTYKVG PLNSHFGFSV AEHFNGKNPI LLIGAPKANS
SQPGTISAGA IYSCPLNSYF RYKSTINDKW CSQTYVEYQN KERYKLPPRT KDDRSITIDS
KGNDYQLLGA SVSSSGKING RAIVCAPLKR YHEGVSYTDG SCYVLGTDLT LTSIVHNCNG
GRLSKQERHN SYGACMQGFS SSIDEEVILT GTIGAKAWTG GVHATFVDKS DDVFSINIDR
TTLGFEEREG GIRENKLFEK GDYVGYSVKH GRFGFWYEDK KNFTIVSGST RHNQSGSVVF
FPFMSIQDQS YEEMLPTNDG FMLKGKQIGS GFGYSIEIVD LNNDGFDDLI VGAPYEFYID
EKGSEFHGAV YVYFSSGKFQ SRDQNELVFK KPIILRGNLN RDEYGYDDFA VGAPFDDNGA
GVIYIYFGSK DEKSFNIKAA QIISASKLGI SPRQNPLKSC GFSLSGGSDI DNNGYPDLLV
GCVLSDTVVA LRSKPIINII TDHSMINTSL NIDGGINCPK GSKTCFEFTT ILSMNPSYSK
EKLVDYTKDV FICQLETLPS QLGVDRRAKI YGSKDGYTLN WECGKNLNKQ SQRKSHKLFI
SKDNTDWLNP LKLKFSVSIK DQSKPTLPNE GEPLINLNNY PILNKYNSTH EVLISFNKRC
GDDDKCESDL ELGATFLDIS QDKKGKFVTR VGEKDSINIK FIVKNKGERA YESRMYLQYN
HDELDVPQLD GTKKLSSVNI ESYENNIIIF SLGNPIEPGK IITFHVTFKL VKSEGQRTSN
ILFFKANVNS TSIEKNDKDN IWEEELEIIK EAELELSGVS SPQMNYFGTT IDSLPESELK
YEEDIGPMVK HQYTVTNKGP FYVRDVSVEF DWPFRIDHED GENNYALYLL ETPTIIEADK
SIRHCLVEDA YDYINPQKLI IDPSLKVENI IKQKGRNKRE VEEGKIFNIP EIKISTKGFL
GSKGLEPIEA TDSNGSPIMI VDVHYYYTNI EYVQISSSGR IIVKPEQGVV DDQSNNFFTI
STHAYPDRPK LQTQEVPILP IILAIIVGLL ILGVIILICW KCGFFKRKRA GDGPLLHKAE
LQYEREMWHE MR
//