ID A0A090L6N7_STRRB Unreviewed; 856 AA.
AC A0A090L6N7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=SRAE_2000008700 {ECO:0000313|EMBL:CEF65407.1,
GN ECO:0000313|WBParaSite:SRAE_2000008700.1,
GN ECO:0000313|WormBase:SRAE_2000008700};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65407.1};
RN [1] {ECO:0000313|EMBL:CEF65407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF65407.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_2000008700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000008700.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_2000008700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; LN609529; CEF65407.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090L6N7; -.
DR STRING; 34506.A0A090L6N7; -.
DR EnsemblMetazoa; SRAE_2000008700.1; SRAE_2000008700.1; WBGene00260277.
DR WBParaSite; SRAE_2000008700.1; SRAE_2000008700.1; WBGene00260277.
DR WormBase; SRAE_2000008700; SRP05900; WBGene00260277; -.
DR eggNOG; KOG0973; Eukaryota.
DR OMA; CITANNA; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 127..161
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 174..215
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 652..738
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
SQ SEQUENCE 856 AA; 96810 MW; 76BF0293CC61A208 CRC64;
MLRIHTCSWI SYKNNQIYGI DIHPNGKKFA ICLQVDGGKG NLEMWSMSPI LNDTIPKSTS
PLFNVSFRSG LNSVRWSKYD YGKYLAVSTE DGIILIIEYL GRCRESKGST GEDEEDIKEL
YKTKYELHGH SLSANNAEWS NDGRFLASCG MDGKIIIWNV KKLPEKVVIL NEASGGHTDN
VNGISWDPIG NFLASQSNDK TLKVWSVDDW KVKTTISKPF EGACNSTMFK RMDWSPDGII
LIAPAAMNNK TPATQIVLRK NWDYKKDIIG LRQNSTVVKF MPSLMKVKSE NDEISTVMVC
AIGSRDRSFS LWMFPRYERP LCLIRNLFND TIHDFSWHNN IVGACSSDGS VQFISLKESE
FIKFCSIDEL KSRCQFIHKQ IPIQFRRDDD MLNDSITEDS CLLYKVPKTV PVKTTSIIST
SSIIVEKEPI KNNDKIEKEN STETVKQPKL IVRSKNNATV KITSTQIIKE PEEDIKNQNV
TITQPSMISL ERLIDEQQFV KPALTMEEFN VLLKTKILQE SEEDLLDVSF ESNMETSTIE
RAAVPPTKPM KGKLSFTIPE YKKLLKYITE SKATIVDCIT ANNACQLMPG VNITRVTAKL
GRVIVWETVI TSRVGVVKFN DQYTVLVSYD KTVTILDSKT GRQLIQFIPK EMTCIVFFKN
HWLSLVSEKG KLYIWNLQTF QNSITISLKA IMQTEKELVN VLISPNGIPI IYCENNRVYS
YSTTTNSLIS ISNTSDVITR HALAKICGDL DSHSTGVISS LFDSNKLYSN LTLPDDITQL
SIESDFKKYL HLYAQSLINN GHTEKLEGLI KEIESNKSLI CGHDSTEVID ELQPYKEKNR
SFGNSASKGV DLMESI
//
