ID A0A090L8U2_STRRB Unreviewed; 1593 AA.
AC A0A090L8U2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Afadin {ECO:0000313|EMBL:CEF63925.1, ECO:0000313|WBParaSite:SRAE_1000218100.1};
GN ORFNames=SRAE_1000218100 {ECO:0000313|EMBL:CEF63925.1,
GN ECO:0000313|WBParaSite:SRAE_1000218100.1,
GN ECO:0000313|WormBase:SRAE_1000218100};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF63925.1};
RN [1] {ECO:0000313|EMBL:CEF63925.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000218100.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF63925.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000218100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; LN609528; CEF63925.1; -; Genomic_DNA.
DR STRING; 34506.A0A090L8U2; -.
DR EnsemblMetazoa; SRAE_1000218100.1; SRAE_1000218100.1; WBGene00258795.
DR WBParaSite; SRAE_1000218100.1; SRAE_1000218100.1; WBGene00258795.
DR WormBase; SRAE_1000218100; SRP08412; WBGene00258795; -.
DR eggNOG; KOG1892; Eukaryota.
DR OMA; PAFIVYM; -.
DR OrthoDB; 2881454at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005911; C:cell-cell junction; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01782; RA1_Afadin; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR028842; Afadin.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10398; AFADIN; 1.
DR PANTHER; PTHR10398:SF2; AFADIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 2.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 2.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT DOMAIN 58..148
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 234..357
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 684..921
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT DOMAIN 1043..1128
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1204..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 181207 MW; DE06CFE89410E08E CRC64;
MYDSIDSKSP VESSFLEENF EAKRKYLIEL IENWNENRLE LFAISMPEDD SLEIYGAMRF
YFRDTGEKVF SKCIRVSSTA TTETVIEALV EKFRPDMKML TTPEYSLWEA HENGNERRLG
SEEKPLLVQL NWHKDDKDGR FILKNDNEPE KINRNTGRFS KRLKNELKKR SKSIDNVKGS
NSKLFEEPKT VTEEVFSDAS SNPFNRTISN PEVVMKKRRE QKLENKLKEI MGNNGGSLKI
YGHNINPFKN YVSILVSIYD RASKILIEAL QKYGIENEDP TNFVLTQKIM PHNSVNRMSK
SNSDLREEET EDAVMFNERV LDGDECPLLN LLNHKEKKHD NRTSNEEIIF TLRRRPPPSK
MPPQIVMATQ QTTPSPIYQH LNKHSMINFT TSQYQQPLGV SPTNSVTSSS SQMYGGNIQK
SICKRPALVP INHLTGKENH DSVILIQPNV TIIGSNPDLA QPQNQAILLT GQNVIPRHCL
ISFSDGGVSI TPLDGRGIVE VNERQIISTT LLKDGFTIKI GNVNGFKFYS NYNQNTYFLN
NNLLGSHQIQ STSPSINDPT MPITTHFDAN PYAAPVYPRK GSVSSIYSSQ SPYNLTSNNF
YGNTQQLSIY PPQNLPGLIE VNDQYKNDDL FLSLLITNST IQLINFRPGP AFILYMSLRH
RSCTLYRPSI QMDVRNGLTQ QYFNMICKKI THVVYSSPSN VDSLAFWLTV SSELLFIIQS
DIHLNSILSQ LGDNLFNLVE KCFSLLNDAC HVQLSHTMYS FLNGTIDDVI ASNETISVFE
NIMSQLRRNR TNAALQIQIF SQLFHYVNMY IFNWMVGTEE GARHLTLSWA IHLKERLYHI
YKWAENHGLE LAVECHMDRI QQAVNLLTTP KTVDQVAVLG ATCYKLNSRQ VEYLLTRYIS
DISETPVTES IVNDCIKLSQ SQADESAREE GLSVELLEER RLNVPFMFPQ EGYVIQLQKG
IPSYLMELID YLEQQGVCRF IPLGNINGSW TVHMKNYVHN SETLSQASTE FASSSRHHIN
IPHNQSLSIP NTNYNNMKLQ IVSISFSKIN NGIGLSIVAA QSTENKNVGI YVKKVFEGGA
AHKDGRIETG DQLLSLNEHS LIGISQEAAA DIMAKCGPQL HFKVGKNAAY CNGLSSWFSK
DTENNEKEIK YQQRNINNQT PLYNGTNYNS NLSVNNYSIY RPRTTSESSM QSNFTNNLSK
QTHHLPSHYR TSNRPPIIQP GRPSNYNNTS NISSSSIGYP IHHNDYTSMN QVFNKNMIPS
SVRIRSSSVI PFGQENSSTT SIIPSRHPIN ISTNNQGNNL MIKREYLNSG RRSAPLFGEE
LSPKELREKL NDELDMLEAK GDKMTDYDRL RYREIVQQLG NISTSPQKNL NNTNGLGVRY
RQNHIHQPPP PFLSEMTSKF EQKRQSQSSS MSGSSSNHNH YRNGVESIID TVVADVKKIN
LVVEENQSKE SNFNNRSNFD NDVKLSNSLN ISKNCNSQQV EQLSPNSQEE NKNPLQNNVI
EKNKDDLKMN EQNEDETDEP RVQIIGNNEI YNDPRIRRLN EIQSRSNRTN VDGSNLDFKD
KMKMFAASLG EETPKARIST SSAQREIEHS LEK
//
