ID A0A090LA03_STRRB Unreviewed; 454 AA.
AC A0A090LA03;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=SLC41 divalent cation transporters, integral membrane domain-containing protein {ECO:0000313|EMBL:CEF64330.1, ECO:0000313|WBParaSite:SRAE_1000258500.1};
GN ORFNames=SRAE_1000258500 {ECO:0000313|EMBL:CEF64330.1,
GN ECO:0000313|WBParaSite:SRAE_1000258500.1,
GN ECO:0000313|WormBase:SRAE_1000258500};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF64330.1};
RN [1] {ECO:0000313|EMBL:CEF64330.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000258500.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF64330.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000258500.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749}.
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DR EMBL; LN609528; CEF64330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LA03; -.
DR EnsemblMetazoa; SRAE_1000258500.1; SRAE_1000258500.1; WBGene00259200.
DR WBParaSite; SRAE_1000258500.1; SRAE_1000258500.1; WBGene00259200.
DR WormBase; SRAE_1000258500; SRP11010; WBGene00259200; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF21; PROTEIN CBG01705; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 189..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..247
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 330..423
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 51301 MW; 37759D10370872D2 CRC64;
MKKESNQHSP LVLKSSIEND DSSMPYIDTF REHQKDDNND KKTKIISSDE NDKLCESTNH
SEIINFLPET FYAENIPENN IFIENTKDVG EEIVETAAQF VTQSCVTYLI TGLAFVLSGL
LFENYKEALL GLKGNIETTF ASRLTTAFHC GKLSKGKAKK SYFFVICAST LKLFLKKETT
FNIHFVEQIF VLMAAAISST CLCSLLLGFF LYIIMKYSKQ WDLNPDNFLT PLSASLGDFI
TMIIFLFSGY LLVVIGNSVN SIIRIVIPIF IVSLFIVFSI YCGYVAYNEP TSKKVLKNGW
FPIVIASAVS NIAGLILTDS KLDRNRVTVQ CRDFNSKIAI SQIITSVPAQ YLFVSLSFII
SEAYFVTKYF YLYYGLLSFL LMIILMHLCN VFVHFIWKIK YDPDTVSIPI LTSLTDLLAT
SGLCILLSNI GKGIEYLNFD KNKNIHYETN SIST
//
