ID A0A090LCD1_STRRB Unreviewed; 462 AA.
AC A0A090LCD1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SRAE_2000211900 {ECO:0000313|EMBL:CEF67456.1,
GN ECO:0000313|WBParaSite:SRAE_2000211900.1,
GN ECO:0000313|WormBase:SRAE_2000211900};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF67456.1};
RN [1] {ECO:0000313|EMBL:CEF67456.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000211900.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF67456.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000211900.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; LN609529; CEF67456.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LCD1; -.
DR STRING; 34506.A0A090LCD1; -.
DR EnsemblMetazoa; SRAE_2000211900.1; SRAE_2000211900.1; WBGene00262327.
DR WBParaSite; SRAE_2000211900.1; SRAE_2000211900.1; WBGene00262327.
DR WormBase; SRAE_2000211900; SRP10134; WBGene00262327; -.
DR eggNOG; KOG0891; Eukaryota.
DR OMA; ENFKPVM; -.
DR OrthoDB; 2877978at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0031931; C:TORC1 complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051247; P:positive regulation of protein metabolic process; IEA:UniProt.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 114..426
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 430..462
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 462 AA; 53890 MW; 1A4B9AA763836823 CRC64;
MKNVLEPLHK QIQQDITTMT QKEQSFVYNY KADLDNAWNN CMHYENTKQV KHMHAAWDLY
YNTFKKLTNQ LRNMQTLDMK ICSPDLITYK NFNVVVPGTY NPYSSKDPVM IKEVKRFANV
ISSKQRPRKV IMIGSDGEEY CFLLKGHEDP RQDERVMQLF GLINTLFNKD RRTYRRNLDI
QRYSIIALNE TCGLIGWLPN CDTLHSLIKD YRDKDNINIS AEHTAMQSYV IDLEKCNLMM
KVEAFKNALT ATSGEDLRQT LWLKSPNSEI WFERRTNYTR SMAVMSMVGY LIGLGDRHPS
NLMLDRLSGK IVHIDFGDLF EIATMREKYP EKIPFRLTRI MVRAMEVTGI EGNYRNTCER
VLNLCRTYDD RLLAILEAFV YDPVIGTKLQ SGSKAVNKQY TPPKAIPHTG TAEIERIKQK
LIGRDFAFYH SYEVEGQVNR LIEEATSADN LCQCYVGWCP FW
//
