ID A0A090LDP1_STRRB Unreviewed; 1231 AA.
AC A0A090LDP1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Helix loop helix protein 106 {ECO:0000313|EMBL:CEF67882.1, ECO:0000313|WBParaSite:SRAE_2000254400.1};
GN ORFNames=SRAE_2000254400 {ECO:0000313|EMBL:CEF67882.1,
GN ECO:0000313|WBParaSite:SRAE_2000254400.1,
GN ECO:0000313|WormBase:SRAE_2000254400};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF67882.1};
RN [1] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_2000254400.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000254400.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CEF67882.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF67882.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_2000254400.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; LN609529; CEF67882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LDP1; -.
DR STRING; 34506.A0A090LDP1; -.
DR EnsemblMetazoa; SRAE_2000254400.1; SRAE_2000254400.1; WBGene00262754.
DR WBParaSite; SRAE_2000254400.1; SRAE_2000254400.1; WBGene00262754.
DR WormBase; SRAE_2000254400; SRP11264; WBGene00262754; -.
DR eggNOG; KOG2588; Eukaryota.
DR OrthoDB; 3668492at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062:SF1; LP12374P; 1.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 383..433
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 465..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..450
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1231 AA; 144145 MW; 044358B0A9AD00D3 CRC64;
MTSNNNSYIN YKPSHYNTFE SSNLIEDNFT LDYVKPQELD ELINEDNLLN VLQPEGLNEI
NNIVDSIKND ELNMYSNKNY IEIPYFSNTT NVNDYNNFHI QNEYLQNNQF SEGQTYQSMK
NTDNLINKYD YSFDMPYQNT SFYINKNSQF IPKNTFECMS NNMKVAPLQE NKFDFYPERK
FNYHNGDVSP SQVNNNLSPI SFTSFSSESF DQQNIEYNSV NSSPISNESL FHSTFTTPPL
SKNIYTTTNS FENLETVKNG FNNQITNDFK NINYTDNTKS QSFNNDIISE DDFDEKIEEL
IREAPKKSTT FKNQKNNKRK KRNDLYTEDY NDFTEDITMS NDYEERVNNF NVDEITFDRT
MSLKDRKENE KDYDNVIKKP KTERRKAHNL IEKKYRCSIN VQINQLKEIV AKKDEKLSKS
ATLKKAVDKL NSLMDENEQL YYQIDKLKQG LKSVYEVNLK LRSNQNEKNS SLKSPSNSDY
FSGSDTASPP IKNIQYRKNF NVRNQQYSGS TFIDKLGIPI PDVSLKKTKS QMKKVMDNKS
RVTLCIFMFC MLIFNPISIF SFKTYSNQSS NIRTSYFQNS NNLTTKNILS FSHRILNEIN
NQTAIKSAHV AAMVNETANK ARHWYQNTIM ENTYIWGMNA IIIISILYKL LVSGEPVTDY
NSPSWETFIK LKKSASTAIS KDMLGRPIPK RGFDELLTVF WQIIRHLLNS VWVGRYFSRR
KRSPTQLSDA VCKSHAATAL VYHQLHQLHL IMEDSNSSNN LRGLNLVLNA VNLSESAGIS
NDKLTHAQRA DIYINASIRV RLSFPSYIGN LIGKYFMRRA KRHVRKAAFK NEKFLALNWV
FTSHGKKFLS DIANVHEMIK NIKVNSNIKT YFCRKYTNEE MKPLNHLTIL FKADLIEQLI
DKYQTNKKTS SCSNSFNVSE TIQLLLSIGS CPYDYNNINT NLVDCTDASL LDWNIVLDNY
EFSDEITSWW THLLSAALYW NMGLKMKAQT HYAVVIKVPK EIKECGFTFA TILAFCTKKM
AIDDSFNSKY STTTIYYCMK GIDYINDEIK KGIIHTFTDD VFQRIFHKTK FLTIEWYLSC
LLEVWYSKLN LNFSFWQQPQ KNNTLINVYK TLLKMYTYFI KNYSIDNSLT MKNEFYNFCY
NIMITNTQES IASNYSIFMD KFRLFYNQQS ITHLPSLLHF LKYFVTQEKV HLASFLQYHT
NVHFKIIKKL KDELKYISFN SDESFYEKKN F
//
