ID A0A090LE54_STRRB Unreviewed; 635 AA.
AC A0A090LE54;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Major facilitator superfamily and Major facilitator superfamily domain, general substrate transporter and Major facilitator superfamily associated domain-containing protein {ECO:0000313|EMBL:CEF68037.1};
GN ORFNames=SRAE_2000269800 {ECO:0000313|EMBL:CEF68037.1,
GN ECO:0000313|WBParaSite:SRAE_2000269800.1,
GN ECO:0000313|WormBase:SRAE_2000269800};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF68037.1};
RN [1] {ECO:0000313|EMBL:CEF68037.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000269800.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF68037.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000269800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; LN609529; CEF68037.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LE54; -.
DR STRING; 34506.A0A090LE54; -.
DR EnsemblMetazoa; SRAE_2000269800.1; SRAE_2000269800.1; WBGene00262909.
DR WBParaSite; SRAE_2000269800.1; SRAE_2000269800.1; WBGene00262909.
DR WormBase; SRAE_2000269800; SRP03284; WBGene00262909; -.
DR OMA; GHVRVMY; -.
DR OrthoDB; 5353125at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..545
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
SQ SEQUENCE 635 AA; 70230 MW; F5F2335D7FE725EF CRC64;
MIADSIGDDK VIRIFGREIS RDIFMLKVFY LLYFASFGSL FPLLAVYFKQ LGMTAAQAGL
LLGSRPFIEF ASEPFWGFYA DKFKSGKFLL LFSLGSLVIS TLAIGFVQPQ TPYCVILDKN
ITKDNCMYLA AAGPAIKGGP LGLIKESVGL GRRKRRDASN QIIDTIIDLS SYDKEEDMIP
GIAPEYITSD KVCNYEESQY GILLSPPHSS RVYREPAVEQ AFMLLLLIIL IGEFFSSPAI
VLVDGITLSV VKNTPKMFGR VRLFGSIGWG VAMFIMGIGL DYSDTFKNHP CPIKNTTEKN
YTICFLTCSL FTVLSMIVST QLKFPKSEQQ TKAEEIGGLV MDSRVEEVDP AIAQRTMGKQ
LHAPENTSET FLSKWGALIK ASLNLPFTIY LLSIAIIGFG SGLNFSFLFW HLQDFGGSPT
LFGLCSVVNH IAEVIMFFYS FSVINKYGYV KTMYGLLGAN ILRFLALSWL TNPWMVLPLQ
FVQGIINSLT WACASSYVSL VAPPHLKQQC QRFLALLFNG IARGCGGIIG GFIISYVGTR
TMFQINALIS IIILVSNYCI NKLTKGSGFK YNTYGEFDDD GADAALAPHG IPLISGENNL
QNAFNQTSVI NTNYGTIGQD PQDEAYDRYV SNPYD
//
