UniProt: A0A090LFG2

Database: UniProt
Entry: A0A090LFG2_STRRB

LinkDB:  A0A090LFG2_STRRB 
Original site:  A0A090LFG2_STRRB

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Ontology (3)   
   GO (3)   
Gene (1)   
   WORMBASE (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
All databases (8)   

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ID   A0A090LFG2_STRRB        Unreviewed;       391 AA.
AC   A0A090LFG2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=inx {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=SRAE_2000155400 {ECO:0000313|EMBL:CEF66888.1,
GN   ECO:0000313|WBParaSite:SRAE_2000155400.1,
GN   ECO:0000313|WormBase:SRAE_2000155400};
OS   Strongyloides ratti (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF66888.1};
RN   [1] {ECO:0000313|EMBL:CEF66888.1, ECO:0000313|Proteomes:UP000035682}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC   ECO:0000313|WBParaSite:SRAE_2000155400.1}, and ED321 Heterogonic
RC   {ECO:0000313|EMBL:CEF66888.1};
RA   Martin A.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SRAE_2000155400.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
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DR   EMBL; LN609529; CEF66888.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A090LFG2; -.
DR   STRING; 34506.A0A090LFG2; -.
DR   EnsemblMetazoa; SRAE_2000155400.1; SRAE_2000155400.1; WBGene00261759.
DR   WBParaSite; SRAE_2000155400.1; SRAE_2000155400.1; WBGene00261759.
DR   WormBase; SRAE_2000155400; SRP02151; WBGene00261759; -.
DR   OMA; HNIVINS; -.
DR   OrthoDB; 2873211at2759; -.
DR   Proteomes; UP000035682; Chromosome X.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF20; INNEXIN-3; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        30..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        104..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        190..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        278..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
SQ   SEQUENCE   391 AA;  45946 MW;  9B2C89D8D75FE072 CRC64;
     MLSIPFLEDI VKGWIKKKSF DDPVDRLNHF VTASILGFFA IMVSAKQYLG QPIQCMVPKE
     FSSGWEHYAE DYCFIQNTFY VPFNETIPKE YDDRRKAEIG YYQWVPIILA LQAILFFIPN
     WIWKSLYSQS GIDLNTIITD GMSLRGTGPN DREENSIKLK EYISDCLGMK DIKRNFRIGF
     FKLEKNYGNY ITALYLFIKL LYVLNIICQF ILLNNFLGDY YTMWGLKAIK YKLDGKEWQT
     SSVFPRVTLC DFDVRDLADV HRFTVQCVLM INMFNEKVYL FIWFWFIFVG IVTILNFIYC
     CSHFISLSHR HSAVKYLLKH LMNTKNPREF DKAVKHFTSQ GLKPDGYLIL RFLEGNAGAI
     IAKDITHKLF QDYLITYMDD CIKDCLDPVF S
//

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