ID A0A090LJ73_STRRB Unreviewed; 326 AA.
AC A0A090LJ73;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=LD29161p {ECO:0000313|EMBL:CEF69763.1, ECO:0000313|WBParaSite:SRAE_2000440900.1};
GN ORFNames=SRAE_2000440900 {ECO:0000313|EMBL:CEF69763.1,
GN ECO:0000313|WBParaSite:SRAE_2000440900.1,
GN ECO:0000313|WormBase:SRAE_2000440900};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69763.1};
RN [1] {ECO:0000313|EMBL:CEF69763.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000440900.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF69763.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000440900.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN609529; CEF69763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LJ73; -.
DR STRING; 34506.A0A090LJ73; -.
DR EnsemblMetazoa; SRAE_2000440900.1; SRAE_2000440900.1; WBGene00264641.
DR WBParaSite; SRAE_2000440900.1; SRAE_2000440900.1; WBGene00264641.
DR WormBase; SRAE_2000440900; SRP08889; WBGene00264641; -.
DR OrthoDB; 3015718at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19378; TGF_beta_DAF7; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..326
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 326 AA; 38441 MW; 760FB401783DAFB1 CRC64;
MIIISYCLLY IVLLYFTLLS FVKISLTNDI DEMFARQKIL QSILDHFQLK KPLPIDVSSS
VRKKYENHID KINEHDENKK FVTFFDIPSN KIMFPIIFFK IPKILRSYIF KEGSIKLDYY
SYTDHDEEFF GNIYVTTKDN EIMECIGNVT FEKNLPLNGT INIPLNINLL SKIIDLNEEN
IEIFIKIHKQ NVTFPYLLNF ASLKFHSIDT KERSKRNVEN ICQSKSSENS CCLRLLKINF
DEIGWNFILS PKEINTNYCY GKCYSYKSDS LVGDAIYRLY SISKKEHKRC CYPTQFRELN
ITIFKEGSFI ETKIINDILI KKCSCY
//
