ID A0A090LML5_STRRB Unreviewed; 1022 AA.
AC A0A090LML5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|EMBL:CEF69408.1, ECO:0000313|WBParaSite:SRAE_2000405700.1};
GN ORFNames=SRAE_2000405700 {ECO:0000313|EMBL:CEF69408.1,
GN ECO:0000313|WBParaSite:SRAE_2000405700.1,
GN ECO:0000313|WormBase:SRAE_2000405700};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69408.1};
RN [1] {ECO:0000313|EMBL:CEF69408.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000405700.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF69408.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000405700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN609529; CEF69408.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LML5; -.
DR STRING; 34506.A0A090LML5; -.
DR EnsemblMetazoa; SRAE_2000405700.1; SRAE_2000405700.1; WBGene00264285.
DR WBParaSite; SRAE_2000405700.1; SRAE_2000405700.1; WBGene00264285.
DR WormBase; SRAE_2000405700; SRP00823; WBGene00264285; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..602
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 611..1021
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1022 AA; 114914 MW; 5CD07811758F03EA CRC64;
MENIQKQNRD HVDLMDVDIQ LKSYRYDCSE KSRTNSGFIG DDISLPTSIM EFNKEGRPTL
HDLIKKNIDE DITGNILSGN ITTPKRIDSE SIHEDEKFQG FGWVKGVLLR CILCIIGATL
YMRMSWIAGQ AGIFLGMMVI LLSLIVVTIT AVSMSAIATN GEIKNGGCYY LISRSLGPEF
GGSIGLILYI ANMVNGAMNC VGLAESLVFL FGQLNFKLFD GGINDVRVYG LSTCVILQGI
IFIGTEFENK TQIILLITII LSILSHTIGA FLPVTQEQLK HGIIGFSFKT IMNNFWPDFR
DGNSFITVFG VYFPAMTGIM AGANMSGDLK DPSKSIPIGT MTAIMITTII YSGTMLLSAC
ATVRDSTGFN IPTFPNNNYD LILPTCRQNN TCKFGLANDY QVPLTQAAFS PLIIAGIIAS
TLSSASGCLI GAPRIFQALC QDKLFPGLSY FGKGRGITNE PFNAYFLTFF LTCCVILIGD
LNAISEIITN FFLAAFAITN FACFDSSASK SPGFRPGFKY YNKWLSLFGS VLCISLMFIL
SWVTSLITLF IFAILFLFLK HTVHNVNWGS STEANRYRIA LMELLKLSRH EEHVKNYRPQ
ILVLTGNPIA RQSLVDFTHA IMGGQNLMLC GHVVPYVSSV SATACIRKLN SKMSDIIKER
KWKSFYCSIS NKSLRNGVQG LLQSVGLGKM QPNILLIGFK YNWLKETLDE KYKNDVKEYQ
YVILDAFESN MNLCIFKNGN ERLDHSILLR DFYEKFLNEI PEILMTDKTN SLQEDYLRGY
SSDFSRQYLT ISSSQQLIKH RSLSSIISLG NGSRNSSSND ITADIKISIN DKFRYKINNG
IIDVWWLDND GGLILLIPYL LTTNIHSYLH NASLRIFVIV DSHNINPEKA KENLQKLLHK
FRIKYTEIIV IVEENNKLCP ETEMEYNFYI ELLNPKLNSQ NHLLNSTLLE KYSHKTRQYL
WLREVILKNS IDSNLLIISL PIAHESVILS PLYMIWLDLL SKDMPPILFV KGNNISVLTY
IS
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