ID A0A090LNM2_STRRB Unreviewed; 610 AA.
AC A0A090LNM2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
DE AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|ARBA:ARBA00031085};
GN ORFNames=SRAE_2000377700 {ECO:0000313|EMBL:CEF69125.1,
GN ECO:0000313|WBParaSite:SRAE_2000377700.1,
GN ECO:0000313|WormBase:SRAE_2000377700};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69125.1};
RN [1] {ECO:0000313|EMBL:CEF69125.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF69125.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_2000377700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000377700.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_2000377700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004912}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000256|ARBA:ARBA00010694}.
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DR EMBL; LN609529; CEF69125.1; -; Genomic_DNA.
DR STRING; 34506.A0A090LNM2; -.
DR EnsemblMetazoa; SRAE_2000377700.1; SRAE_2000377700.1; WBGene00264002.
DR WBParaSite; SRAE_2000377700.1; SRAE_2000377700.1; WBGene00264002.
DR WormBase; SRAE_2000377700; SRP11288; WBGene00264002; -.
DR eggNOG; KOG1372; Eukaryota.
DR OrthoDB; 5484740at2759; -.
DR UniPathway; UPA00128; UER00190.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR013657; SCL35B1-4/HUT1.
DR NCBIfam; TIGR01472; gmd; 1.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF08449; UAA; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..596
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 610 AA; 68898 MW; 125F2F90380F7409 CRC64;
MDISSPVPLT ILTCTSCMFF IELLSKKKEN CMVFLTFCTF AFIAIHGLIF TSKFFTVKRN
IPLRVYFKIA FIFFIVNLSN NQSLQYNISV PICIIFRSAS LLVNMAMGYL FLNKKYTLKK
LISVVIVTLG IYSFIVVSDH SVPKKETTIS GFAIGITLLS VALILSSYLG ILQENMYKEY
GKYPQEASFY TYLISLPYFL IFSNEICLAV VEFEVTNIIM IVLICLFQLF CINNVYILTT
ELSSLGVTMV LTLRKFISVI ISVFYFGHNL SIMSEGSKKI ALITGITGQD GSYLAELLIA
KGYSVHGIIR RSSTFNTHRI AHLYADPNIH KGSSTFQLHY GDMTDSSCLI KLISKIQPTE
IYHLAAQSHV KVSFDLPEYT AEVDAVGTLR LLDAIVACNL QHKVKFYQAS TSELYGKVQE
IPQKETTPFY PRSPYAVAKL YAFWIIKNYR EAYGIFACNG ILFNHESPRR GVQETLSLGN
LDAKRDWGHA KEYVEAMWRI LQHDVADDFV ISTGKTESVR EFCNLAFAEI GMKLIWQGEG
VNEVGIEEKT GKVRVRVDPN YYRPTEVDLL IGDPTKAKEV LGWEAKITLK ELVKEMVASD
VELMKANPNA
//