ID A0A090MLM6_STRRB Unreviewed; 417 AA.
AC A0A090MLM6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
GN ORFNames=SRAE_2000290510 {ECO:0000313|EMBL:CEG06136.1,
GN ECO:0000313|WBParaSite:SRAE_2000290510.1,
GN ECO:0000313|WormBase:SRAE_2000290510};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEG06136.1};
RN [1] {ECO:0000313|EMBL:CEG06136.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000290510.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEG06136.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000290510.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361183};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361183};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LN609529; CEG06136.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090MLM6; -.
DR STRING; 34506.A0A090MLM6; -.
DR EnsemblMetazoa; SRAE_2000290510.1; SRAE_2000290510.1; WBGene00263122.
DR WBParaSite; SRAE_2000290510.1; SRAE_2000290510.1; WBGene00263122.
DR WormBase; SRAE_2000290510; SRP08392; WBGene00263122; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001506; Peptidase_M12A.
DR InterPro; IPR006026; Peptidase_Metallo.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10127:SF887; ASTACIN-LIKE METALLOENDOPEPTIDASE; 1.
DR PANTHER; PTHR10127; DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING; 1.
DR Pfam; PF01400; Astacin; 1.
DR Pfam; PF00431; CUB; 1.
DR PRINTS; PR00480; ASTACIN.
DR SMART; SM00235; ZnMc; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS51864; ASTACIN; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Hydrolase {ECO:0000256|RuleBase:RU361183};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361183};
KW Metalloprotease {ECO:0000256|RuleBase:RU361183};
KW Protease {ECO:0000256|RuleBase:RU361183};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU361183};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..264
FT /note="Peptidase M12A"
FT /evidence="ECO:0000259|PROSITE:PS51864"
FT DOMAIN 259..299
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 108..263
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT DISULFID 263..273
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 289..298
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 417 AA; 49462 MW; 00B13F5285FB6F41 CRC64;
MINLEKFFLY SAFYILYIFP YIITSAYFSL NDEYLEKGNV KRSIEKIINF KYDNEIMDDL
SINNRKKRNI KIKLGKFRWD SFIDYYVSFP LGHSKIKKVI NVLETTTCLR FREAKSLYGC
VSGILFVSST RCHSHLGRET DRNWQRIEIA RECYNEGEIL QLILRTLGVI YEHNRVDRNY
FVQVVEENIL PFAKKHFELF RKSVFNDKFL PYEYGSIMHF GMYNYSRNGG KTLVTFNRLY
ENTMGQHDMI TFNDIRTLNM HFCSDVCRNR IICENYGYQN PNNCNQCLCI EGYAGVSCEK
TAKTRPFCSK SVFLVTNKPL FWNITGVKHC VYHLKANNFH KIKIVLLKVR MDTSFSMMCS
SSDTLEIKFL RNKSLTGARF CHQKFPKFIK SHDNYVIIQY KSYDPRSFVH MYFKSSH
//
