ID A0A090MWL3_STRRB Unreviewed; 1247 AA.
AC A0A090MWL3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Myosin heavy chain {ECO:0000313|EMBL:CEF63884.1, ECO:0000313|WBParaSite:SRAE_1000214000.1};
GN ORFNames=SRAE_1000214000 {ECO:0000313|EMBL:CEF63884.1,
GN ECO:0000313|WBParaSite:SRAE_1000214000.1,
GN ECO:0000313|WormBase:SRAE_1000214000};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF63884.1};
RN [1] {ECO:0000313|EMBL:CEF63884.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000214000.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF63884.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000214000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; LN609528; CEF63884.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090MWL3; -.
DR STRING; 34506.A0A090MWL3; -.
DR EnsemblMetazoa; SRAE_1000214000.1; SRAE_1000214000.1; WBGene00258754.
DR WBParaSite; SRAE_1000214000.1; SRAE_1000214000.1; WBGene00258754.
DR WormBase; SRAE_1000214000; SRP10411; WBGene00258754; -.
DR eggNOG; KOG0161; Eukaryota.
DR OMA; KERRMQM; -.
DR OrthoDB; 640507at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF706; MYOSIN-11; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..795
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 671..693
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 859..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1247 AA; 145515 MW; 2522B051D02051CA CRC64;
MVVQLEWLTD PGWPYLRQMP DEALKEQAAR KFDNKTHTWI PDPDDGFSIA EIMVAEGPTL
SVKLSNGSTR KISKDQCQEI NPSKFEKTED MANLTFLNEA SVLHNLRERY SSMMIYTYSG
LFCVFINPYK MLPIYTDSVI QMYNNQRRSE MPPHLFAVSD EAYRNMITDK QNQSMLITGE
SGAGKTENTK KVIAYFAKIG GSDEQKINPL KKTVSFSDFP VGGSLEDKVV QANPAIEAFG
NGKTNRNNNS SRYGKFIRIH FDKNGKLVGG DIESYLLEKS RVIKQGPGER SFHIFYQIMT
NKKLRKEYLL SNNIKDYHFV SQAEVTVPGM NDTEEMSITD NAFNVMGFAG EEKNDLYKLC
GAIMHMGEMK FKQKPREEQA EVDSMNAVDN VCKLFSINGE KFIQALLKPQ VKVGTEWVSR
GQNLQQVEWS VQALAKAIYA RMFKWLIDRC NETLSTNLSE SVNYIGVLDI AGFEIFDTNS
FEQLWINFVN EKLQQFFNHH MFVLEQEEYQ REGISWEFID FGLDLQNCID LIEKPLGIIS
MLDEECIVPK ATDMTYAEKL KNQHLGKHSN FQAAKPPRGK QGEAHFAIIH YAGTVRYNVV
AWLEKNKDPL NDSAVAVLKT SDKNNLIYKI FEDYQTEADR EEAHQRGKEL ARKKGKSASF
MTVSNIYKES LNNLMCMLHT THPHFIRCII PNEIKKSGEI DAQLVLNQLT CNGVLEGIRI
CRKGFPNRML FDDFKYRYAI LAADESRLPE IKNACSKMMD KLVKAKKIKE EDFRVGETKV
FFKTGILAKL EEYRDAALSV IILKFQAQAR FYLAQIELKE RERKINAIID LQRNIRRWIK
IGNWNWYKLY IRLKPLMVGF KTQEEMEALE RKIKEMEEML AAANEENKKI KAIQNETVKR
EEELKINIQN EQKEKQMFDK KIKEYEEALE KEKQINIERE NKALEREAKI ERERKRLEEE
IFRQKQEMET MTMKHTIQLE ELTQKLLLQG DISEQMNQQR KIQEQAKLEL MDELERMGNK
VEHLEKQRIN SLEELNKFED KINNEKKLKE EQIKLRKKLE NEIKQLIDKI ELLQNKNNVL
EKELKERYDE SVRLKNKNFS EITLISKMQT NIRQLIERIS QIEDELDIET RARTRAEKSK
ADLQRELDDA LQTITELTGQ LNAQMHINKN KQLELAGLQR EMDKKHIGFE THLSDLCSMQ
LSTLNNLRKL STQAKFLEHE TNMVLEHRKP CEIKRSYSLT NYDDDKE
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