ID A0A090MWY5_STRRB Unreviewed; 1671 AA.
AC A0A090MWY5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Kalirin {ECO:0000313|EMBL:CEF64494.1, ECO:0000313|WBParaSite:SRAE_1000274800.1};
GN ORFNames=SRAE_1000274800 {ECO:0000313|EMBL:CEF64494.1,
GN ECO:0000313|WBParaSite:SRAE_1000274800.1,
GN ECO:0000313|WormBase:SRAE_1000274800};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF64494.1};
RN [1] {ECO:0000313|EMBL:CEF64494.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000274800.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF64494.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000274800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; LN609528; CEF64494.1; -; Genomic_DNA.
DR STRING; 34506.A0A090MWY5; -.
DR EnsemblMetazoa; SRAE_1000274800.1; SRAE_1000274800.1; WBGene00259364.
DR WBParaSite; SRAE_1000274800.1; SRAE_1000274800.1; WBGene00259364.
DR WormBase; SRAE_1000274800; SRP02878; WBGene00259364; -.
DR eggNOG; KOG4240; Eukaryota.
DR OMA; FYDHDEW; -.
DR OrthoDB; 2906033at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR PANTHER; PTHR22826:SF106; TRIO, ISOFORM A; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT DOMAIN 29..164
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1245..1424
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1443..1548
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1561..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 370..397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 594..621
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1561..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1671 AA; 193693 MW; D61A4F1BA65F0007 CRC64;
MSPSALEQSN ATSLVRRATD ILHVLRDKIA LLPGSRDRHD HPIIIIPSKD ASYILNGDDV
RNVLFYLHSV TSASSKNNGF IFIIDTRKGV KSENVKLVLK VIQDHFPGLV YEVFIIRSDS
FWEKQKSTGK YKFKVQKLSV EELTKYIDAS QLPTEIGGFM KYDHEEWIEN RLEIETVIWK
ICDIMSAFDK FKKEMNKAEF PFDVNSAEQA IVQHSSVSKF IQDASMEQID NEIKKISHKI
TGGIINSPDD GYNSSLSISA INPDLAAVIP HLGKLLETLR QNKDEIFKEW EHRRKSLDHC
YQLKLFEQDA EKLFEWIRSH YNLTVQRMTD LGENEELATI YLQDHTDFKK AAENTYVSVT
HIITVAKRLK EQGHVNKNKI ENIAKRLEEE WKLFEQRIEQ RLTLLQLSVS FHKRANFYLS
NSNSWKSNIG VDPSNFIDAP SDKLEIAIAE HEKFGDKINQ AYAEAIADGR SLSNQLKATC
RSSPELSGQL GSSQLIEEMN QQITKVHKEI HLTWHKRKVK LHARLAMLAF KNDIQLVISW
LEQHGEPYLG KNIAIGENLQ ASKSLLKNHQ HFKTVASNTY SNAQKIFKAS QTLMENGECD
IKEMNNVVEN LRKRLDKFSE RIEARTILLN KAILFYTHFM ELMQWYDKQD LKSSSYEIVD
IDVEKCEKRR DEWIRETEAT GQACATTITE GQQLINCLYD QAQSMNIENK DVIKYIEVLI
GQIKQRQNLL SERFGRQRTC LQIALRNAVL ILDCEQIQVQ LINWKKDMSN LITCEPDKAE
NVLPFHNENT YKVKKAVAEV KATANGLLQV IDSNGINLRN EVNEPIRDLI INAVKKVKLL
EDEVMQASAN VCQRMENAIQ INRIRIDASR TIQIMQREET QLLRMNRIPQ NFEEAEAFQE
QHDNFQRVVE EKVRPSTINF CQRAQGLRSN FISADENELI NAMIMNVTRK WSRLVCLIEE
RSKLLKSADA CYKSLHQNVL PILEQLEHDY KSDQKDFCSL KPYDKRTELA KLISEKLEKH
EQWKERFVKG SAYAQKTSEN FLKYIRRCGA PEDHIKQREE EIKNVKENLR ERQSRILKMW
SNRKKAYEQC QQAVLIQATE QRISQWLQDE GETFMAQLPT VIALKNSPHT KEQLEAWKGK
LSEFKKILKN EREQVKTFLS AAEGYLKNGI NDIHSSTTER AIQKVKENFS SFCQRMQEIE
LQILTSLGNQ RNSGTKNEFS LDRVSDSSLD EKIQKRTSSG IVDAKLMEPM KELLKSERDY
VVDLETCFNV YIKTYRASTS SLPGSLKGKE KEIFGNIEAL KVFHSEIFMK ELEKYEENPE
EVGNSFITWM DKLNELYTTY CVNKEQNNHI ISMQECLLFF NEVRQRHSLE HNKDLQSMVI
KPVQRITRYR LMLEQLLRNA KSNIDEIKEA YDVVVDVPRK ANDMIHLKRL EGYDEDDVTM
GEFVMQETFL VSDNKHLFKK ARERQVFLFE LCIIFAKKIE VTPKIHKYVT KDKLMLADVS
IREHVEGDIC KFSLRMGNLP NSDMSIDLKS KTEKSKMIWI KRIRDLMQGL LQYNIGLSTM
NNDSDSKRSS RTSAVSKDSA ELALPPTDTI TEGNHKTISE RLQVKQIGNF EEYKQNEENN
TTTSDLNNTL TNDNILSPTK KVLENVVTTE DVEKAVPKLY DILSTVSFND E
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