ID A0A090MWZ5_STRRB Unreviewed; 593 AA.
AC A0A090MWZ5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CEF64544.1, ECO:0000313|WBParaSite:SRAE_1000279800.1};
GN ORFNames=SRAE_1000279800 {ECO:0000313|EMBL:CEF64544.1,
GN ECO:0000313|WBParaSite:SRAE_1000279800.1,
GN ECO:0000313|WormBase:SRAE_1000279800};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF64544.1};
RN [1] {ECO:0000313|EMBL:CEF64544.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000279800.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF64544.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000279800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; LN609528; CEF64544.1; -; Genomic_DNA.
DR STRING; 34506.A0A090MWZ5; -.
DR EnsemblMetazoa; SRAE_1000279800.1; SRAE_1000279800.1; WBGene00259414.
DR WBParaSite; SRAE_1000279800.1; SRAE_1000279800.1; WBGene00259414.
DR WormBase; SRAE_1000279800; SRP08272; WBGene00259414; -.
DR OMA; MKQAYAQ; -.
DR OrthoDB; 2876625at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF482; BETAINE RECEPTOR ACR-23; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 23..593
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5015031353"
FT TRANSMEM 280..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 315..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 345..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 559..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 65..279
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 287..571
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 593 AA; 68476 MW; 1BFFBC8113AFE9D0 CRC64;
MKLILIYIFI IIYFTSFKST FTQTFDDDTV GKLNISVNDG LFFSYQKIPY YTLEENSGIS
SFYKLESYLL NNYNPNIIPQ RKRDNSVNVL FTINLYQIIE INELQQYIKI NCWVVERWED
PMLYWDPNDF EGIDEIVLPE HNVWKPDTTL YNSLVMEDSA SKRLQHVKLN TNNITKTTTV
EMLYPAIYKS SCIIDLRYFP FDYTRCILTF GSWIYDNKAI DYFHESNESI SQAIGTKHCL
PNEGFDILST YVERKVMKYA CCVNNYTLLE YSLYIQRKPL YYIVNLVAPT GIISLIAIIG
FFSSSTLNDV REEKISLGIT TLLSMTFIIL AVSDKMPSTS AFIPLIGWFY NSMILLISLG
TLAASYVIYV QKKGIIGKRP EGRVMKIFVI LGKLLWLEIP LLMKQAYAEK ARLEKLKKAN
QKKMSVWQKW QSLSKDVKKM KKSSSMLNSS NIIDNSNMLS SLINNQTTKT DDDTTFDFKS
SIITNDDVSV GNPSVSEYDT FSVGKNEKNK LNLLGSLEDD SLYKYIANDG GKDFQGVIKQ
TRNLAEIEYD WLAAVVERFF LLTFILLFIM LGVGINFIGL YHWLDTREQL VKK
//
