ID   A0A090MZQ4_STRRB        Unreviewed;       745 AA.
AC   A0A090MZQ4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|ARBA:ARBA00016310, ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN   ORFNames=SRAE_2000398900 {ECO:0000313|EMBL:CEF69339.1,
GN   ECO:0000313|WBParaSite:SRAE_2000398900.1,
GN   ECO:0000313|WormBase:SRAE_2000398900};
OS   Strongyloides ratti (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69339.1};
RN   [1] {ECO:0000313|EMBL:CEF69339.1, ECO:0000313|Proteomes:UP000035682}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC   ECO:0000313|WBParaSite:SRAE_2000398900.1}, and ED321 Heterogonic
RC   {ECO:0000313|EMBL:CEF69339.1};
RA   Martin A.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SRAE_2000398900.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   EMBL; LN609529; CEF69339.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A090MZQ4; -.
DR   EnsemblMetazoa; SRAE_2000398900.1; SRAE_2000398900.1; WBGene00264216.
DR   WBParaSite; SRAE_2000398900.1; SRAE_2000398900.1; WBGene00264216.
DR   WormBase; SRAE_2000398900; SRP04248; WBGene00264216; -.
DR   OMA; KPTKMRI; -.
DR   OrthoDB; 7264at2759; -.
DR   Proteomes; UP000035682; Chromosome X.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368024};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          36..448
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          518..740
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   745 AA;  85184 MW;  27E6CBF71DC7834D CRC64;
     MLLNQLSNIC GTSSFSKISN LLRYASTIKI NTSEYPLIRK DKNVVETLHG IQIADPYRYL
     EDPLNEETTN FIKKLNDISS KVFEKSNIRG IIKERLREYI NYEKHDVLFK HGDYYYYSHN
     TGLQNHNTIC RKKTLDDKEE IFLDVNKLSK DGLISCSSMK FSNDGSIMAY GLSINGSDWN
     TIKFKTSDNK DVDDILEKVK HSNSDFLFNN TGFIYSTYPN RKESDTGRTV TKNEYHSLYY
     HKMGTSQKDD VLIVDYPQDK EVFTFGSISN DEKYLFVYFN KGTDPKNMIY YYDLSKNMDK
     TFKGKIKLEP LFDKGDASYE IIDSNENEVI VKTDKNAPLG KIIKVKFSEA HKGESAWTVL
     IDELKERKIS DVTVVGKDYL LLNCLENVRS SLYMYNKHTG EMIQKFDIDI GIVYQVSGDD
     KSNEFFFGFL NQITPGIIYR GYLDNSESNN KFKIEKIIEN NSKNLNSKDF SVKQVFYKSK
     DNKDISMFIF HRKDMKLDGN NPVLLEGYGG FSISMTPSFS VSKSMFVKHF NGISCIANIR
     GGGEYGEEWH IDGMLHKKQN CFDDFIGAAE YLVSNKYTNP SKLAIRGGSN GGLLMAAVSQ
     QRPDLFGAVI NSVGVLDMLR FHKFTAGGAW IAEYGNPEIK EDFDYLLKYS PLHNLEMPPE
     PIQWPNTLLK TADHDDRVVP SHTLKYIATL YEVLQTGSKY QTNPVIAKIE KSSGHGSGKP
     LSKALDEIVD DYSFLQQVLD INWKN
//