ID A0A090MZR8_STRRB Unreviewed; 1027 AA.
AC A0A090MZR8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|EMBL:CEF69409.1, ECO:0000313|WBParaSite:SRAE_2000405800.1};
GN ORFNames=SRAE_2000405800 {ECO:0000313|EMBL:CEF69409.1,
GN ECO:0000313|WBParaSite:SRAE_2000405800.1,
GN ECO:0000313|WormBase:SRAE_2000405800};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF69409.1};
RN [1] {ECO:0000313|EMBL:CEF69409.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_2000405800.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF69409.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_2000405800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN609529; CEF69409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090MZR8; -.
DR STRING; 34506.A0A090MZR8; -.
DR EnsemblMetazoa; SRAE_2000405800.1; SRAE_2000405800.1; WBGene00264286.
DR WBParaSite; SRAE_2000405800.1; SRAE_2000405800.1; WBGene00264286.
DR WormBase; SRAE_2000405800; SRP10915; WBGene00264286; -.
DR OMA; FRINFTH; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..608
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 617..1025
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1027 AA; 114346 MW; 7884F42BA653D9EA CRC64;
MEVSNIIEKK HSTLSERHDN INAFIKRYNS NFSLDKSCRR TSCFDDENVV ALKSNSECFS
ANKLTLRDSI QKLPQSEDSS ATDFCPIGVV SENGMLSITT KNQFQGFGWV KGVLLRCILC
IIGATLYMRM SWIAGQAGIF LGMMVILLSL IVVTITAVSM SAIATNGEIK NGGCYYLISR
SLGPEFGGSI GLILYIANMV NGAMNCVGLA ESLVFLFGQL NFKLFDGGIN DVRVYGLSTC
VILQGIIFIG TEFENKTQII LLITIILSIL SHTIGAFLPV TQEQLKHGII GFSFKTIMNN
FWPDFRDGNS FITVFGVYFP AMTGIMAGAN MSGDLKDPSK SIPIGTMTAI MITTIIYSGT
MLLSACATVR DSTGFNIPTF SNNNYDLILP TCRQNNTCKF GLANDYQVPL TQAAFSPLII
AGIIASTLSS ASGCLIGAPR IFQALCQDKL FPGLSYFGKG RGITNEPFNA YFLTFFLTCC
VILIGDLNAI SEIITNFFLA AFAITNFACF DSSASKSPGF RPGFKYYNKW LSLFGSVLCI
SLMFILSWVT SLITLFIFAI LFLYLKHLAK TVNWGSSYEA NRYRIALMEL LKLSRHEEHV
KNYRPQFLVL TGNPAARQCL VDFTYSISGG QNLMICGHVV PYKSSVSATD FIRNLNSRLT
DWLKDQKIKA FYCGVANKSL RMGVQALLQT VGLGKMQPNI LMIGFKQNWI KQVRKNDEKI
YVTEYLGVIL DALLSNMSIC IFRNGNDKLD HSMDLANRYD GLMLQLSDKQ LMEAESGLHD
DFLLGREIEK IRPVAGIISK TGIIKNKSVG SLINISFNTR KVSNVVYSAN SRINLGKKFR
CKIKEGDIDV WWLNDDGGLT LLIPHLLVVN TQSFLHEANL RVFVICSPTA NPKETKTEME
RLLNKFRINF THVMVIVEED NDLYRETVDE YNGYLEILNP KDDPENHTIK SDLLESFSAK
TKQYLRLREL LLEHSAASHL VILTLPIAHE SVIISPLYLL WLEVLTKDMP PTLLTRGNNT
PVLTSLS
//
