ID   A0A090T1E7_9VIBR        Unreviewed;       952 AA.
AC   A0A090T1E7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Protease insulinase family {ECO:0000313|EMBL:GAL32504.1};
GN   ORFNames=JCM19240_5936 {ECO:0000313|EMBL:GAL32504.1};
OS   Vibrio maritimus.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=990268 {ECO:0000313|EMBL:GAL32504.1, ECO:0000313|Proteomes:UP000029224};
RN   [1] {ECO:0000313|EMBL:GAL32504.1, ECO:0000313|Proteomes:UP000029224}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19240 {ECO:0000313|EMBL:GAL32504.1,
RC   ECO:0000313|Proteomes:UP000029224};
RA   Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M., Ohkuma M.;
RT   "Vibrio maritimus JCM 19240. (C210) whole genome shotgun sequence.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAL32504.1, ECO:0000313|Proteomes:UP000029224}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19240 {ECO:0000313|EMBL:GAL32504.1,
RC   ECO:0000313|Proteomes:UP000029224};
RG   NBRP consortium;
RA   Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M., Ohkuma M.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAL32504.1}.
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DR   EMBL; BBMT01000002; GAL32504.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A090T1E7; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000029224; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 2.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:GAL32504.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029224};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          62..179
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          219..393
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          539..647
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          686..858
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   952 AA;  105972 MW;  EB43D0BEB01180F4 CRC64;
     MRKIWLGLLS VVFVYGCSNS DVSTQTASAL PPGITLVEEM KADPDRVMIP YSKYKLDNGL
     TVILAPDDSD PLVHVDVTYH VGSAREEIGK SGFAHFFEHM MFQGSEHVGD QQHFKIITEA
     GGTLNGTTTR DRTNYFETVP SNQLEKMLWL EADRMGFLLG AVSQRKFEIQ RDTVKNERAQ
     NFDNRPYGLI WERMGEAMFP EGHPYSWQPI GYVEDLDRVN VNDLKAFFLR WYGPNNAVLT
     IGGDIDNAQT LEWIHKYFGT IPEGPSVEKA PKQPAVLPED RYITLEDRIR QPMVVIGWPT
     TSYRGAEDQV VLDAMADAIG GGTNGLLYQK LIKTQKALDA GAFSDCNELA CNFYVYAMGA
     STDKDGLKSL YNDLLATLDE FEKQGISEER LQQINGLSEA GAVYALESVK GKVTQLAANE
     TFYGKPDRIE QTLERIRAVT PEAVSAAYQT FIEDKHKVTL SVVPKGRTDI AVKPATFVTP
     PRTLPEYKEV TEADLDFRRP VDSFDRSVMP EVAEAVSAKM PELYEVYFDN GSELLGTETS
     ETPTVEIHFQ LPAGSRYVPE GKEGLAGLTA SMMEEGTTTR TVEQLQAELD RLGSQIGFSE
     GAYTTRVSVS ALERNLPQTL TLLEDMLFNP AMKQEDFDRL KAQTLEGLVY QHQKPSWMAS
     QATRDVLYGD SVFGRSSDGS NASISSITLD DVKAFYREHY TPQGAQIVVV GDISKKQITD
     QLAFWSLWHG EAAPLIDPEV IPSLAGQKIY LVDKPSAPQS IVRMVRQGLP FDATGELYLS
     RLANFNLAGN FNSRINQNLR EDKGYTYGAS GYFASNREVG AIVFSAQVRA DATLASLEEM
     IAELKNYSEN GMTDEELAFM RLAVGQQDAL TYETPSQKAS LLSSILTYSL DKDYLKQRND
     IVATVDKSTL NALATKWFDP SQYQLIVVGD AKRLKPQLEK LNIPITELEI SQ
//