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Database: UniProt
Entry: A0A090T3M3_9VIBR
LinkDB: A0A090T3M3_9VIBR
Original site: A0A090T3M3_9VIBR 
ID   A0A090T3M3_9VIBR        Unreviewed;       281 AA.
AC   A0A090T3M3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-MAY-2019, entry version 27.
DE   RecName: Full=Urease {ECO:0000256|SAAS:SAAS00325551};
DE            EC=3.5.1.5 {ECO:0000256|SAAS:SAAS00325551};
GN   ORFNames=JCM19239_5002 {ECO:0000313|EMBL:GAL26147.1};
OS   Vibrio variabilis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=990271 {ECO:0000313|EMBL:GAL26147.1, ECO:0000313|Proteomes:UP000029223};
RN   [1] {ECO:0000313|EMBL:GAL26147.1, ECO:0000313|Proteomes:UP000029223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19239 {ECO:0000313|EMBL:GAL26147.1,
RC   ECO:0000313|Proteomes:UP000029223};
RA   Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M.,
RA   Ohkuma M.;
RT   "Vibrio variabilis JCM 19239. (C206) whole genome shotgun sequence.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GAL26147.1, ECO:0000313|Proteomes:UP000029223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19239 {ECO:0000313|EMBL:GAL26147.1,
RC   ECO:0000313|Proteomes:UP000029223};
RG   NBRP consortium;
RA   Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M.,
RA   Ohkuma M.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|SAAS:SAAS01119912};
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|SAAS:SAAS00608819};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1.
CC       {ECO:0000256|SAAS:SAAS00317636}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PROSITE-
CC       ProRule:PRU00700, ECO:0000256|SAAS:SAAS00548017}.
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases
CC       superfamily. Urease alpha subunit family.
CC       {ECO:0000256|RuleBase:RU004158, ECO:0000256|SAAS:SAAS00849550}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAL26147.1}.
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DR   EMBL; BBMS01000015; GAL26147.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAL26147; GAL26147; JCM19239_5002.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000029223; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-EC.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000029223};
KW   Cytoplasm {ECO:0000256|PROSITE-ProRule:PRU00700,
KW   ECO:0000256|SAAS:SAAS00317631};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700,
KW   ECO:0000256|SAAS:SAAS00321417, ECO:0000313|EMBL:GAL26147.1};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00321440};
KW   Nickel {ECO:0000256|SAAS:SAAS00317628};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029223}.
FT   DOMAIN       55    281       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    246    246       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     143    143       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
SQ   SEQUENCE   281 AA;  29550 MW;  980B10F171B2E1FA CRC64;
     MLDYWGIIKA DVAVKNGRIQ ALGKAGNPDI QPGVDIIVGP CTEVLAGEGS ILTAGGIDSH
     IHFICPQQIE EALASGVTTM IGGGTGPNTG TNATTCTPGP WNMHRMLESL DQFPMNFGLL
     GKGNASQPEA LREQIAAGAV GLKLHEDWGT TPASIDTCLT VADEMDVQVA IHTDTLNESG
     FVESTLGAIG DRVIHTYHTE GAGGGHAPDI IKAAGESNVL PSSTNPTRPY TVNTVDEHLD
     MLMVCHHLSP SIAEDVAFAE SRIRRETIAA EDILHDLGAF L
//
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