ID A0A090TZ78_9VIBR Unreviewed; 1159 AA.
AC A0A090TZ78;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=JCM19240_1619 {ECO:0000313|EMBL:GAL36177.1};
OS Vibrio maritimus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=990268 {ECO:0000313|EMBL:GAL36177.1, ECO:0000313|Proteomes:UP000029224};
RN [1] {ECO:0000313|EMBL:GAL36177.1, ECO:0000313|Proteomes:UP000029224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 19240 {ECO:0000313|EMBL:GAL36177.1,
RC ECO:0000313|Proteomes:UP000029224};
RA Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M., Ohkuma M.;
RT "Vibrio maritimus JCM 19240. (C210) whole genome shotgun sequence.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAL36177.1, ECO:0000313|Proteomes:UP000029224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 19240 {ECO:0000313|EMBL:GAL36177.1,
RC ECO:0000313|Proteomes:UP000029224};
RG NBRP consortium;
RA Sawabe T., Meirelles P., Nakanishi M., Sayaka M., Hattori M., Ohkuma M.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAL36177.1}.
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DR EMBL; BBMT01000009; GAL36177.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090TZ78; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000029224; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR048472; DNA_pol_IIIA_C.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:GAL36177.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000029224};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:GAL36177.1}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1159 AA; 130135 MW; CA5EEF9BDA6B0955 CRC64;
MSDPKFIHLR VHSDFSMVDG LSKVPPLVKK VAELGMPAVA LTDFTNLCGL VKFYGNAHSA
GIKPLIGADF SVQSDEFGEE LTRITVLAAD NTGYNNLTLL ISKAYLRGHV QHQPVIDKAW
LAELSEGLIV LSGAKDGEVG KALLKGNQSL AKQCAAFYQT HFADRFYLEL IRTGRADEES
YLHFAIDLAE ELELPVVATN EVVFVDKELF DAHEIRVAIH DGYTLDDPRR PKRYSDQQYL
RSEEEMCELF ADIPEALQNS VEIAKRCNVT VRLGEYFLPA FPTEGMKETD FLVMKSREGL
EERLEFLFPD EQVRLERRPE YDERLQIELD VINQMGFPGY FLIVMEFIQW SKDNAIPVGP
GRGSGAGSLV AYALKITDLD PLEYDLLFER FLNPERVSMP DFDVDFCMDK RDQVIDHVAE
MYGRDAVSQI ITFGTMAAKA VIRDVGRVLG HPFGFVDRIS KLIPGDPGMT LQKAFDVEPA
LPQLYDNDEE VRDLIDMCRI LEGCTRNAGK HAGGVVISPT TITDFAPIYA DSEGHFPVTQ
FDKNDVETAG LVKFDFLGLR TLTIIDWALG LINPRLEKEG KEPVRIESIP LDDQPSFQLL
QNSETTAVFQ LESRGMKELI KRLQPDCFED IIALVALFRP GPLQSGMVDN FIDRKHGREA
VSYPDETWQH ESLKETLEPT YGIILYQEQV MQIAQILAGY TLGGADMLRR AMGKKKPEEM
AKQRAVFEEG AINNGVDGEL AMKIFDLVEK FAGYGFNKSH SAAYALVSYQ TLWLKRHYPA
EFMAAVMTAD MDNTEKVVGL VDECFRMKLK VLPPDINAGL FRFNVNDEGA IVYGIGAIKG
VGEGPIDAII EARNKDGYFR DLFDFCARID LKKVNKRVIE KLIMAGALDK LGPHRAALMA
SLNDAVKAAS QHHQAEAFGQ GDMFGVLTDA PEEVEHKYTQ VPAWPEKVWL EGERETLGLY
LTGHPINAYL KELTKYTSCR LKDATPTRRD QSLTVAGLVI AARVMTTKRG TRIGIMTLDD
RSGRMEVMLF SDALDKYAEL LEKDKIVVVS GQVSFDDFNG GLKMSAREVL DLGSAREKFT
RGLSISLLEQ QIDERFYQRF TEILTPHKDG TVPVNIYYQR ADARAKLTLG TQWRVTPNDA
LLEELQQLLG KDQVELEFN
//
