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Database: UniProt
Entry: A0A090W4U5_9FLAO
LinkDB: A0A090W4U5_9FLAO
Original site: A0A090W4U5_9FLAO 
ID   A0A090W4U5_9FLAO        Unreviewed;       330 AA.
AC   A0A090W4U5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Delta-aminolevulinic acid dehydratase {ECO:0000256|ARBA:ARBA00020771, ECO:0000256|RuleBase:RU000515};
DE            EC=4.2.1.24 {ECO:0000256|ARBA:ARBA00012053, ECO:0000256|RuleBase:RU000515};
GN   ORFNames=JCM19300_2590 {ECO:0000313|EMBL:GAL62537.1};
OS   Algibacter lectus.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Algibacter.
OX   NCBI_TaxID=221126 {ECO:0000313|EMBL:GAL62537.1, ECO:0000313|Proteomes:UP000029644};
RN   [1] {ECO:0000313|EMBL:GAL62537.1, ECO:0000313|Proteomes:UP000029644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19300 {ECO:0000313|EMBL:GAL62537.1,
RC   ECO:0000313|Proteomes:UP000029644};
RA   Takatani N., Nakanishi M., Meirelles P., Mino S., Suda W., Oshima K.,
RA   Hattori M., Ohkuma M., Hosokawa M., Miyashita K., Thompson F.L., Niwa A.,
RA   Sawabe T., Sawabe T.;
RT   "Draft Genome Sequences of Marine Flavobacterium Algibacter lectus Strains
RT   SS8 and NR4.";
RL   Genome Announc. 2:e01168-14(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen;
CC         Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00001227,
CC         ECO:0000256|RuleBase:RU000515};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
CC       {ECO:0000256|ARBA:ARBA00004694}.
CC   -!- SUBUNIT: Homooctamer. {ECO:0000256|RuleBase:RU000515}.
CC   -!- SIMILARITY: Belongs to the ALAD family. {ECO:0000256|ARBA:ARBA00008055,
CC       ECO:0000256|RuleBase:RU004161}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAL62537.1}.
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DR   EMBL; BBNQ01000006; GAL62537.1; -; Genomic_DNA.
DR   RefSeq; WP_042504425.1; NZ_FOLN01000008.1.
DR   AlphaFoldDB; A0A090W4U5; -.
DR   OrthoDB; 9805001at2; -.
DR   UniPathway; UPA00251; UER00318.
DR   Proteomes; UP000029644; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004655; F:porphobilinogen synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04823; ALAD_PBGS_aspartate_rich; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR001731; ALAD.
DR   InterPro; IPR030656; ALAD_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   PANTHER; PTHR11458; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   PANTHER; PTHR11458:SF0; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; 1.
DR   Pfam; PF00490; ALAD; 1.
DR   PIRSF; PIRSF001415; Porphbilin_synth; 1.
DR   PRINTS; PR00144; DALDHYDRTASE.
DR   SMART; SM01004; ALAD; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS00169; D_ALA_DEHYDRATASE; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000515};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001415-5};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU000515};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029644}.
FT   ACT_SITE        196
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-1"
FT   ACT_SITE        254
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-1"
FT   BINDING         239
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001415-5"
SQ   SEQUENCE   330 AA;  36772 MW;  6169A9A16C22E83E CRC64;
     MYPLRRNRRL RTNEAIRSLV RETVITPNDF LVPLFVVEGK GIKDEIASMP NYFRYSLDLL
     EGEIKELWSL GLKSVLLFVK VPDHLKDNKG TEALNPNGLM QRAIKTIKNV CPDMLVMTDV
     ALDPYSSFGH DGIVQNGMIV NDESTAVLSQ MALTHAQAGA DFVAPSDMND GRTLQIRQLL
     ENEGFKNTGI MSYSAKYASA FYGPFRDALD SAPVDLVDVP KDKKTYQMDC GNRIEAIRET
     LMDIDEGSDI VMVKPGLSYL DILRDIKNEV DVPVAVYQVS GEYAMIKAAA EKGWLNHDEV
     MMETTMAFKR AGADIIASYF AKDVVKILNG
//
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