ID A0A091CMG3_FUKDA Unreviewed; 212 AA.
AC A0A091CMG3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Protein shisa-5 {ECO:0000256|ARBA:ARBA00040441};
DE AltName: Full=Scotin {ECO:0000256|ARBA:ARBA00041983};
DE Flags: Fragment;
GN ORFNames=H920_20051 {ECO:0000313|EMBL:KFO18623.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO18623.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO18623.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO18623.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC a role in p53/TP53-dependent apoptosis.
CC {ECO:0000256|ARBA:ARBA00037507}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the shisa family.
CC {ECO:0000256|ARBA:ARBA00038108}.
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DR EMBL; KN125357; KFO18623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091CMG3; -.
DR STRING; 885580.ENSFDAP00000001888; -.
DR eggNOG; ENOG502S2Y4; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395:SF14; PROTEIN SHISA-5; 1.
DR PANTHER; PTHR31395; SHISA; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 82..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 179..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO18623.1"
SQ SEQUENCE 212 AA; 22565 MW; 9B4694E1D1403C23 CRC64;
AHGEVCTAAL GDNSSPKLCP DFCCGSCSNQ YCCSDVLKRI VWTEDACAVP EASVPTSTEP
WEQLGSALRF RSSFDDDPMS GFGATVAIGL TIFVLSVVTI IICFTCSCCC LYKMCRRPRP
IVTTTTATTV VHAPYPQPPS APPSYPGPTY QGYHPMPPQP GMPAAPYPMQ YPPPYPAQPM
GPPAYHETLT GGAAASQPPY NPAYVDPPKA VP
//
