ID   A0A091CRA7_FUKDA        Unreviewed;       774 AA.
AC   A0A091CRA7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
DE   Flags: Fragment;
GN   ORFNames=H920_17870 {ECO:0000313|EMBL:KFO20707.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO20707.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO20707.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO20707.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KN124601; KFO20707.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091CRA7; -.
DR   STRING; 885580.ENSFDAP00000016223; -.
DR   eggNOG; KOG2285; Eukaryota.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          397..632
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO20707.1"
SQ   SEQUENCE   774 AA;  90325 MW;  065B086865496A4A CRC64;
     LKNKGSLQFE DKWDFMRPIV LKLLRQESVT KQQWFDLFSD VHAVCLWDDK GPAKIHQALK
     EDILEFIKQA QARVLSHQDD TALLKAYIVE WRKFFTQCDI LPKPFCQLEI TLMGKQGSNK
     KTNVEDSIVR KLMLDTWNES IFSNIKNRLQ DSAMKLVHAE RLGEAFDSQL VIGVRESYVN
     LCSNPEDKLQ IYRDNFEKAY LDSTERFYRT QAPSYLQQNG VQNYMKYADA KLKEEEKRAL
     RYLETRRECN SVEALMECCV NALVTSFKET ILAECQGMIK RNETEKLHLM FSLMDKVPNG
     IEPMLKDLEE HIISAGLADM VAAAETITTD SEKYVEQLLT LFNRFSKLVK EAFQDDPRFL
     TARDKAYKAV VNDATIFKLE LPLKQKGVGL KTQPESKCPE LLANYCDMLL RKTPLSKKLT
     SEEIEAKLKE VLLVLKYVQN KDVFMRYHKA HLTRRLILDI SADSEIEENM VEWLREVGMP
     ADYVNKLARM FQDIKVSEDL NQAFKEMHKN NKLALPADSV NIKILNAGAW SRSSEKVFVS
     LPTELEDLIP EVEEFYKKNH SGRKLHWHHL MSNGIITFKN EVGQYDLEVT TFQLAVLFAW
     NQRPREKISF ENLKLATELP DAELRRTLWS LVAFPKLKRQ VLLYEPQVSS PKDFTEGTLF
     SVNQEFSLIK NAKVQKRGKI NLIGRLQLTT ERMREEENEG IVQLRILRTQ EAIIQIMKMR
     KKISNAQLQT ELVEILKNMF LPQKKMIKEQ IEWLIEHKYI RRDESDINTF IYMA
//