ID A0A091CRL8_FUKDA Unreviewed; 395 AA.
AC A0A091CRL8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Phospholipase A2 group XV {ECO:0000256|ARBA:ARBA00039788};
DE EC=3.1.1.32 {ECO:0000256|ARBA:ARBA00013179};
DE EC=3.1.1.4 {ECO:0000256|ARBA:ARBA00013278};
DE EC=3.1.1.5 {ECO:0000256|ARBA:ARBA00013274};
DE AltName: Full=1-O-acylceramide synthase {ECO:0000256|ARBA:ARBA00042012};
DE AltName: Full=LCAT-like lysophospholipase {ECO:0000256|ARBA:ARBA00042195};
DE AltName: Full=Lysophospholipase 3 {ECO:0000256|ARBA:ARBA00042321};
DE AltName: Full=Lysosomal phospholipase A and acyltransferase {ECO:0000256|ARBA:ARBA00041990};
DE AltName: Full=Lysosomal phospholipase A2 {ECO:0000256|ARBA:ARBA00042250};
GN ORFNames=H920_18642 {ECO:0000313|EMBL:KFO20015.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO20015.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO20015.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO20015.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38739, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75757, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036246};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38740;
CC Evidence={ECO:0000256|ARBA:ARBA00036246};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38723, ChEBI:CHEBI:74669, ChEBI:CHEBI:76063,
CC ChEBI:CHEBI:76064, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036334};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38724;
CC Evidence={ECO:0000256|ARBA:ARBA00036334};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-
CC glycerol; Xref=Rhea:RHEA:38707, ChEBI:CHEBI:74669, ChEBI:CHEBI:75936,
CC ChEBI:CHEBI:76055, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036286};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38708;
CC Evidence={ECO:0000256|ARBA:ARBA00036286};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-
CC hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol; Xref=Rhea:RHEA:38711,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76061, ChEBI:CHEBI:76062,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000256|ARBA:ARBA00036488};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38712;
CC Evidence={ECO:0000256|ARBA:ARBA00036488};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38727, ChEBI:CHEBI:74669, ChEBI:CHEBI:75542,
CC ChEBI:CHEBI:75868, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00035806};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38728;
CC Evidence={ECO:0000256|ARBA:ARBA00035806};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-
CC hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol; Xref=Rhea:RHEA:38735,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:75455, ChEBI:CHEBI:76065,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000256|ARBA:ARBA00036773};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38736;
CC Evidence={ECO:0000256|ARBA:ARBA00036773};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-
CC octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol;
CC Xref=Rhea:RHEA:38743, ChEBI:CHEBI:74669, ChEBI:CHEBI:75735,
CC ChEBI:CHEBI:75938, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036060};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38744;
CC Evidence={ECO:0000256|ARBA:ARBA00036060};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-
CC hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol;
CC Xref=Rhea:RHEA:38731, ChEBI:CHEBI:64757, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:75867, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036450};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38732;
CC Evidence={ECO:0000256|ARBA:ARBA00036450};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O =
CC (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine +
CC H(+); Xref=Rhea:RHEA:38699, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30823, ChEBI:CHEBI:74669, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00001885};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38700;
CC Evidence={ECO:0000256|ARBA:ARBA00001885};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-
CC glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-
CC eicosatetraenoylamino]ethyl (9Z)-octadecenoate; Xref=Rhea:RHEA:38751,
CC ChEBI:CHEBI:2700, ChEBI:CHEBI:74669, ChEBI:CHEBI:76070,
CC ChEBI:CHEBI:76083; Evidence={ECO:0000256|ARBA:ARBA00036812};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38752;
CC Evidence={ECO:0000256|ARBA:ARBA00036812};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-
CC octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate;
CC Xref=Rhea:RHEA:38747, ChEBI:CHEBI:71466, ChEBI:CHEBI:74669,
CC ChEBI:CHEBI:76068, ChEBI:CHEBI:76083;
CC Evidence={ECO:0000256|ARBA:ARBA00036160};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38748;
CC Evidence={ECO:0000256|ARBA:ARBA00036160};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-
CC enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38703, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74669, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000256|ARBA:ARBA00036964};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38704;
CC Evidence={ECO:0000256|ARBA:ARBA00036964};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38791, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76076;
CC Evidence={ECO:0000256|ARBA:ARBA00036379};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38792;
CC Evidence={ECO:0000256|ARBA:ARBA00036379};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38803, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:76073, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000256|ARBA:ARBA00036555};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38804;
CC Evidence={ECO:0000256|ARBA:ARBA00036555};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38767, ChEBI:CHEBI:46979, ChEBI:CHEBI:74667,
CC ChEBI:CHEBI:76054, ChEBI:CHEBI:76078;
CC Evidence={ECO:0000256|ARBA:ARBA00036618};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38768;
CC Evidence={ECO:0000256|ARBA:ARBA00036618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine;
CC Xref=Rhea:RHEA:38763, ChEBI:CHEBI:28610, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74667, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000256|ARBA:ARBA00035794};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38764;
CC Evidence={ECO:0000256|ARBA:ARBA00035794};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC (4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine +
CC 1-hexadecanoyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38819,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:72998, ChEBI:CHEBI:74963,
CC ChEBI:CHEBI:76087; Evidence={ECO:0000256|ARBA:ARBA00036476};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38820;
CC Evidence={ECO:0000256|ARBA:ARBA00036476};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-
CC glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-
CC hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-
CC docosahexaenoyl)-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:38815,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:74963, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76085; Evidence={ECO:0000256|ARBA:ARBA00035942};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38816;
CC Evidence={ECO:0000256|ARBA:ARBA00035942};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62484, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:77890,
CC ChEBI:CHEBI:145782; Evidence={ECO:0000256|ARBA:ARBA00036251};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62485;
CC Evidence={ECO:0000256|ARBA:ARBA00036251};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38771, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73003, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000256|ARBA:ARBA00036327};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38772;
CC Evidence={ECO:0000256|ARBA:ARBA00036327};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:38775, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73003, ChEBI:CHEBI:76077, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000256|ARBA:ARBA00036198};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38776;
CC Evidence={ECO:0000256|ARBA:ARBA00036198};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-
CC (5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-
CC hexadecanoyl-sn-glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38839,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73004, ChEBI:CHEBI:73009,
CC ChEBI:CHEBI:76080; Evidence={ECO:0000256|ARBA:ARBA00035931};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38840;
CC Evidence={ECO:0000256|ARBA:ARBA00035931};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphoethanolamine; Xref=Rhea:RHEA:38843,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:73009, ChEBI:CHEBI:76077,
CC ChEBI:CHEBI:76091; Evidence={ECO:0000256|ARBA:ARBA00036513};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38844;
CC Evidence={ECO:0000256|ARBA:ARBA00036513};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine +
CC H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:62488, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:61042,
CC ChEBI:CHEBI:145783; Evidence={ECO:0000256|ARBA:ARBA00035944};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62489;
CC Evidence={ECO:0000256|ARBA:ARBA00035944};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:38807, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72998, ChEBI:CHEBI:73002, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000256|ARBA:ARBA00036046};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38808;
CC Evidence={ECO:0000256|ARBA:ARBA00036046};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphocholine; Xref=Rhea:RHEA:38811, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73002, ChEBI:CHEBI:76077, ChEBI:CHEBI:76084;
CC Evidence={ECO:0000256|ARBA:ARBA00036613};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38812;
CC Evidence={ECO:0000256|ARBA:ARBA00036613};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38835, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73008, ChEBI:CHEBI:76086;
CC Evidence={ECO:0000256|ARBA:ARBA00036667};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38836;
CC Evidence={ECO:0000256|ARBA:ARBA00036667};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38831, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73008, ChEBI:CHEBI:76077, ChEBI:CHEBI:76090;
CC Evidence={ECO:0000256|ARBA:ARBA00036653};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38832;
CC Evidence={ECO:0000256|ARBA:ARBA00036653};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-
CC phosphocholine + H(+); Xref=Rhea:RHEA:38779, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001; Evidence={ECO:0000256|ARBA:ARBA00001126};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38780;
CC Evidence={ECO:0000256|ARBA:ARBA00001126};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) +
CC hexadecanoate; Xref=Rhea:RHEA:38783, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071; Evidence={ECO:0000256|ARBA:ARBA00036275};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38784;
CC Evidence={ECO:0000256|ARBA:ARBA00036275};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38755, ChEBI:CHEBI:46979, ChEBI:CHEBI:72998,
CC ChEBI:CHEBI:73001, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000256|ARBA:ARBA00036333};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38756;
CC Evidence={ECO:0000256|ARBA:ARBA00036333};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38759, ChEBI:CHEBI:46979, ChEBI:CHEBI:73001,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76077;
CC Evidence={ECO:0000256|ARBA:ARBA00036331};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38760;
CC Evidence={ECO:0000256|ARBA:ARBA00036331};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-
CC octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-
CC 3-phosphoethanolamine; Xref=Rhea:RHEA:38823, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73004, ChEBI:CHEBI:73007, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000256|ARBA:ARBA00036629};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38824;
CC Evidence={ECO:0000256|ARBA:ARBA00036629};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-
CC phosphoethanolamine; Xref=Rhea:RHEA:38827, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73007, ChEBI:CHEBI:76077, ChEBI:CHEBI:76088;
CC Evidence={ECO:0000256|ARBA:ARBA00036571};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38828;
CC Evidence={ECO:0000256|ARBA:ARBA00036571};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O =
CC 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62480, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:77756, ChEBI:CHEBI:145781;
CC Evidence={ECO:0000256|ARBA:ARBA00036312};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62481;
CC Evidence={ECO:0000256|ARBA:ARBA00036312};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O =
CC 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate;
CC Xref=Rhea:RHEA:62464, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:78207, ChEBI:CHEBI:145780;
CC Evidence={ECO:0000256|ARBA:ARBA00036098};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62465;
CC Evidence={ECO:0000256|ARBA:ARBA00036098};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-
CC (acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine +
CC 2-nonadioyl-sn-glycero-3-phosphocholine; Xref=Rhea:RHEA:62472,
CC ChEBI:CHEBI:46979, ChEBI:CHEBI:76077, ChEBI:CHEBI:78207,
CC ChEBI:CHEBI:145780; Evidence={ECO:0000256|ARBA:ARBA00036069};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:62473;
CC Evidence={ECO:0000256|ARBA:ARBA00036069};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) +
CC hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435,
CC ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16870, ChEBI:CHEBI:72998;
CC Evidence={ECO:0000256|ARBA:ARBA00000597};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436;
CC Evidence={ECO:0000256|ARBA:ARBA00000597};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-
CC eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57116, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:74965, ChEBI:CHEBI:76080;
CC Evidence={ECO:0000256|ARBA:ARBA00036713};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57117;
CC Evidence={ECO:0000256|ARBA:ARBA00036713};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-
CC (acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-
CC glycero-3-phosphocholine; Xref=Rhea:RHEA:57120, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:74965, ChEBI:CHEBI:76074, ChEBI:CHEBI:76079;
CC Evidence={ECO:0000256|ARBA:ARBA00036902};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57121;
CC Evidence={ECO:0000256|ARBA:ARBA00036902};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-
CC phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-
CC octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-
CC 3-phosphocholine; Xref=Rhea:RHEA:57108, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:73858, ChEBI:CHEBI:76086, ChEBI:CHEBI:84822;
CC Evidence={ECO:0000256|ARBA:ARBA00035904};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57109;
CC Evidence={ECO:0000256|ARBA:ARBA00035904};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-
CC (acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57148, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72827, ChEBI:CHEBI:72845, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000256|ARBA:ARBA00035877};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57149;
CC Evidence={ECO:0000256|ARBA:ARBA00035877};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-
CC sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-
CC glycerol); Xref=Rhea:RHEA:57144, ChEBI:CHEBI:46979,
CC ChEBI:CHEBI:72845, ChEBI:CHEBI:76074, ChEBI:CHEBI:141490;
CC Evidence={ECO:0000256|ARBA:ARBA00035951};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57145;
CC Evidence={ECO:0000256|ARBA:ARBA00035951};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-
CC sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine;
CC Xref=Rhea:RHEA:57136, ChEBI:CHEBI:46979, ChEBI:CHEBI:76054,
CC ChEBI:CHEBI:78260, ChEBI:CHEBI:84467;
CC Evidence={ECO:0000256|ARBA:ARBA00036442};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57137;
CC Evidence={ECO:0000256|ARBA:ARBA00036442};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-
CC serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-
CC sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine;
CC Xref=Rhea:RHEA:57140, ChEBI:CHEBI:46979, ChEBI:CHEBI:76074,
CC ChEBI:CHEBI:77342, ChEBI:CHEBI:78260;
CC Evidence={ECO:0000256|ARBA:ARBA00035838};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57141;
CC Evidence={ECO:0000256|ARBA:ARBA00035838};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-
CC 4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38795, ChEBI:CHEBI:46979, ChEBI:CHEBI:73858,
CC ChEBI:CHEBI:75034, ChEBI:CHEBI:76054;
CC Evidence={ECO:0000256|ARBA:ARBA00036148};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38796;
CC Evidence={ECO:0000256|ARBA:ARBA00036148};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
CC + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-
CC enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
CC Xref=Rhea:RHEA:38799, ChEBI:CHEBI:46979, ChEBI:CHEBI:75034,
CC ChEBI:CHEBI:76071, ChEBI:CHEBI:76074;
CC Evidence={ECO:0000256|ARBA:ARBA00036796};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38800;
CC Evidence={ECO:0000256|ARBA:ARBA00036796};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:18689,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:57875; EC=3.1.1.32;
CC Evidence={ECO:0000256|ARBA:ARBA00036688};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18690;
CC Evidence={ECO:0000256|ARBA:ARBA00036688};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000150};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15178;
CC Evidence={ECO:0000256|ARBA:ARBA00000150};
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
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DR EMBL; KN124866; KFO20015.1; -; Genomic_DNA.
DR RefSeq; XP_010610608.1; XM_010612306.2.
DR AlphaFoldDB; A0A091CRL8; -.
DR STRING; 885580.ENSFDAP00000018539; -.
DR GeneID; 104854027; -.
DR CTD; 23659; -.
DR eggNOG; KOG2369; Eukaryota.
DR OrthoDB; 353098at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003386; LACT/PDAT_acylTrfase.
DR PANTHER; PTHR11440; LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR11440:SF47; PHOSPHOLIPASE A2 GROUP XV; 1.
DR Pfam; PF02450; LCAT; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..395
FT /note="Phospholipase A2 group XV"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001871237"
SQ SEQUENCE 395 AA; 45104 MW; 0637EFC194FA81FB CRC64;
MFLLLLLMLL ADPALSVQRH PPVVLVPGDL GNQLEAKLDK PTVVHYLCSK RTDSYFTLWL
NLELLLPVII DCWVDNIRLV YNRTSGTTHF PDGVDVRVPG FGKTFSLEFL DPSRSSVGSY
FHAMVDSLVG WGYTRGEDVR GAPYDWRRAP NENMDYFLAL QEMVEEMYQL YGGPVVLVAH
SMGNMYTLYF LQQQPQAWKD KYIHTFVSLG APWGGVAKTL RVLASGDNNR IPVIESLKIR
EQQRSAVSTS WLLPYSHTWS PEKVFVRTPT TNYTLRDYHR FFQDIGFEDG WFMRQNTDGL
VEAMLPPGVP LHCLYGTGVP TPDSFYYESF PDHDPKIYFG DGDGTVNLES ALHCRTWKRQ
QEHQVLLQEI RGSEHIEMLA NATTLAYLKR VLLGP
//
