ID   A0A091CU39_FUKDA        Unreviewed;      1244 AA.
AC   A0A091CU39;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Potassium channel subfamily T member 1 {ECO:0000313|EMBL:KFO21498.1};
GN   ORFNames=H920_17139 {ECO:0000313|EMBL:KFO21498.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21498.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO21498.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO21498.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; KN124375; KFO21498.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091CU39; -.
DR   STRING; 885580.ENSFDAP00000008569; -.
DR   eggNOG; KOG3193; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR003929; K_chnl_BK_asu.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR047871; K_chnl_Slo-like.
DR   PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR   PANTHER; PTHR10027:SF14; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1; 1.
DR   Pfam; PF03493; BK_channel_a; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:KFO21498.1};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        158..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          315..382
FT                   /note="Potassium channel"
FT                   /evidence="ECO:0000259|Pfam:PF07885"
FT   DOMAIN          540..634
FT                   /note="Calcium-activated potassium channel BK alpha
FT                   subunit"
FT                   /evidence="ECO:0000259|Pfam:PF03493"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1216..1244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1244 AA;  140513 MW;  9F4A1FAB7F36CA38 CRC64;
     MPLPHGADSP GGYSNCTFEF DDGPRTPRQP CAGDGDGGRG DELPDAAASF RMSDLDSEVL
     PLPPRYRFRD LLLGDQPFPS EDRTAVYGRC CKAGLLWPKE VAEEKWAART KRLQVEDFSL
     DSSLSQVQVE FYVNENTFKE RLKLFFIKNQ RSSLRIRLFN FSLKLLTCLL YIVRVLLDNP
     ARGIGCWGCT KHNYTFNALS SEINWAPILW VERKLTLWVI QVIVATISFL ETMLLIYLSY
     KGNIWEQIFR VSFVLEMINT LPFIITVGNL FIPVFLNCWL AKHALENMIN DFHRAILRTQ
     SAMFNQVLIL FCTLLCLVFT GTCGIQHLER AGENLDLLTS FYFCIVTFST VGYGDVTPKI
     WPSQLLVVIM ICVALVVLPL QFEELVYLWM ERQKSGGNYS RHRAQTEKHV VLCVSSLKID
     LLMDFLNEFY AHPRLQDYYV VILCPTEMDI QVRRVLQIPL WSQRVIYLQG SALKDQDLMR
     AKMDNGEACF ILSSRNEVDR TAADHQTILR AWAVKDFAPN CPLYVQILKP ENKFHVKFAD
     HVVCEEECKY AMLALNCVCP ATSTLITLLV HTSRGQEGQE SPEQWQRMYG RCSGNEVYHI
     RMGDSKFFRE YEGKSFTYAA FHAHKKYGVC LIGLKREDSK SILLNPGPRH ILAASDTCFY
     INITKEENSA FIFKQEERQK QRGLTGQGLY QGPSRPTVRD PPGTVAMDLQ NAECQPAQGG
     GSKLTLPAEN GSGSRRPSIA PVLELADSSA LLPCDLLSDP SEDEATPSED EGVSAVEYVK
     GYPPNSPYIG SSPTLCHLLP VKAPFCCLRL DKGCKHNSYE DAKAYGFKNK LIIVSAETAG
     NGLYNFIVPL RAYYRPRKEL NPIVLLLDNR PDHHFLEAIC CFPMVYYMEG SVDNLDSLLQ
     CGIIYADNLV VVDKESTMSA EEDYMADAKT IVNVQTMFRL FPSLSITTEL THPSNMRFMQ
     FRAKDSYSLA LSKLEKRERE NGSNLAFMFR LPFAAGRVFS ISMLDTLLYQ SFVKDYMITI
     TRLLLGLDTT PGSGYLCAMK VTEDDLWIRT YGRLFQKLCS SSAEIPIGIY RTECHVFSSE
     PQDLRAQVSA PFCTVPPQGT PPSELLQAPE TPVPEAWPLA VSLLLCCLCR RSERQELSEL
     VKNRMKHLGL PTTGYEDVAN LTASDVMNRV NLGYLQDEMN DQQNTLSYVL INPPPDTRLE
     PNDIVYLIRS DPLAHMASSS PSHQSSCSNK LSSCNPGTRD ETQL
//