ID A0A091CU54_FUKDA Unreviewed; 907 AA.
AC A0A091CU54;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Guanine nucleotide exchange factor VAV2 {ECO:0000313|EMBL:KFO21518.1};
GN ORFNames=H920_17159 {ECO:0000313|EMBL:KFO21518.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21518.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21518.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21518.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN124375; KFO21518.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091CU54; -.
DR STRING; 885580.ENSFDAP00000008529; -.
DR eggNOG; KOG2996; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20868; C1_VAV2; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd10406; SH2_Vav2; 1.
DR CDD; cd11980; SH3_VAV2_1; 1.
DR CDD; cd11977; SH3_VAV2_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035880; VAV2_SH2.
DR InterPro; IPR035733; VAV2_SH3_1.
DR InterPro; IPR035732; VAV2_SH3_2.
DR PANTHER; PTHR45818:SF4; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50890; PUA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..907
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012655552"
FT DOMAIN 237..439
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 468..570
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 581..630
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 644..710
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 731..825
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 845..906
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 703..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 103808 MW; 92F02F8740B1D30A CRC64;
MGSCSFVLLQ TPLLGFHFLC LKNIRTFLKV CHDRFGLRNS ELFDPFDLFD VRDFGKWGRR
LEDGPCPFSS AHLMEKSDRE LVSKAALATV RQAVARLLLV CLGLSFPIHQ GEIGPLRAAT
PPWQGAVQTE DVCAEIFKAM MAQAQEVISA VSRLSLHSIA QNKGIRPFPS EETAENDDDV
YRSLEELADE HDLGEDIYDC VPCEDEGDDI YEDIIKVEVQ QPMIRYMQKM GMTEDDKRSC
CLLEIQETEA KYYRTLEDIE KACSQPLGPD AVATLDGQDV LRWDENYMGP LRLVLSPADI
AAVFINLEDL TKVHHSFLRA IDVSMMAGGG TLAKVFLEFK ERLLIYGEYC SHMEHAQSTL
NQLLASREDF RQKVEECTLK VQDGKFKLQD LLVVPMQRVL KYHLLLKELL SHSTDRPERQ
QLKEALEAMQ DLAMYINEVK RDKETLKKIS EFQSSIENLQ VKLEEFGRPK IDGELKVRSI
VNHTKQDRYL FLFDKVVIVC KRKGYSYELK EVIELLFHKM TDDPMHNKDI KKWSYGFYLI
HLQGKQGFQL FCKTEDMKRR WMEQFEMAMS NIKPDKANAN HHSFQMYTFD RTTSCKACRM
FLRGTFYQGY LCTRCGVGAH KECLEVMPPC KITSPADPDT SGAGPGPKMV AVQNYNGNPA
PPGKPVLTFQ TGDVIELLRG DPESQWWEGR LVQTRKSGCF PSSSVKPCPV DGRPPMSRPP
SREMDYTAYP WFAGNMERQQ TDNLLKGHAS GTYLVRERPA EAERFAISIK FNDEVKHIKV
VEKDSWVHIT EAKKFESLSE LVEYYQSHSL KESFKQLDTT LRHPYKSRER AAPRASSRSP
VFTPRVVGTA VARYNFAARD MRELSLREGD VVKIYSRIGG DQGWWKGETN GRIGWFPSTY
VEEEGVQ
//
