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Database: UniProt
Entry: A0A091CU82_FUKDA
LinkDB: A0A091CU82_FUKDA
Original site: A0A091CU82_FUKDA 
ID   A0A091CU82_FUKDA        Unreviewed;      2857 AA.
AC   A0A091CU82;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-FEB-2018, entry version 19.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|EMBL:KFO21553.1};
GN   ORFNames=H920_17057 {ECO:0000313|EMBL:KFO21553.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21553.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO21553.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO21553.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN124359; KFO21553.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KFO21553.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2398   2420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2432   2450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2519   2544       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2564   2586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2694   2717       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      302    356       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      393    449       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      456    535       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      541    597       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1730   1750       {ECO:0000256|SAM:Coils}.
FT   COILED     2795   2815       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2857 AA;  324507 MW;  5CD66300B9E48F39 CRC64;
     MTKPFFHSLS KKYSNMLFLE VDVGACLDLA AEFEVKCMPA FQFFRKGAKM VFPSRPGLQG
     DTLCRKQEQA KVHAAAPAPA RPGTWTTLPR ELPGLYKLPP ATSKCSNHVD VLLKCFLKLA
     GVGGEEEEEE VVVVVEEEEA GGGERKRTPR GGIFLSKYSG AEDKGAGFAF LAGQTLAIEC
     LTRVRIFEKD MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP
     KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL
     LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR
     SIGDSVVIGD KVVLNPVNAG QPLHASSHQL VDNPGCNEGD VVRLFHAEQE KFLTCDEHRK
     KQHVFLRTTG RQSATSATSS KALWEVEVVQ HDPCRGGAGY WNSLFRFKHL ATGHYLAAEV
     DPEFEEECLE YQPSVDPDQD ASRSRLRNAQ EKMVYSLVSV PEGNDISSIF ELDPTTLRGG
     DSLVPRNSYV RLRHLCTNTW VHSTNIPIDK EEEKPVMLKI GTSPVKEDKE AFAIVPVSPA
     EVRDLDFAND ASKVLGSIAG KLEKGTITQN ERRSVTKLLE DLVYFVTGGT NSGQDVLEVV
     FSKPNRERQK LMREQNILKQ IFKLLQAPFT DCGDGPMLRL EELGDQRHAP FRHICRLCYR
     VLRHSQQDYR KNQEYIAKQF GFMQKQIGYD VLAEDTITAL LHNNRKLLEK HITAAEIDTF
     VSLVRKNREP RFLDYLSDLC VSMNKSIPVT QELICKAVLN PTNADILIET KLVLSRFEFE
     GVSSGENALE AGEDEEEVWL FWRDSNKEIR SKSVRELAQD AKEGQKEDRD VLSYYRQVGG
     HVELGLRYQL NLFARMCLDR QYLAINEISG QLDVDLILRC MSDENLPYDL RASFCRLMLH
     MHVDRDPQEQ VTPVKYARLW SEIPSEIAID DYDSSGASKD EIKERFAQTM EFVEEYLRDV
     VCQRFPFSDK EKNKLTFEVV NLARNLIYFG FYNFSDLLRL TKILLAILDC VHVTTIFPIS
     KMAKGEENKG NNDVEKLKSS NVMRSIHGVG ELMTQVVLRG GGFLPMTPMA AAPEGNVKQV
     EPEKEDIMVM DTKLKIIEIL QVLLILNTLK NKLKASLEEG NEENTPLDLD DHGGRTFLRV
     LLHLTMHDYP PLVSGALQLL FRHFSQRQEV LQAFKQVQLL VTSQDVDNYK QIKQDLDQLR
     SIVEKSELWV YKGQGPDEIM DGASGENEHK KTEEGNNKSQ KHESTSSYNY RVVKEILIRL
     SKLCVQESAS VRKSRKQQQR LLRNMGAHAV VLELLQIPYE KAEDTKMQEI MRLAHEFLQN
     FCAGNQQNQA LLHKHINLFL NPGILEAVTM QHIFMNNFQL CSEINERVVQ HFVHCIETHG
     RNVQYIKFLQ TIVKAEGKFI KKCQDMVMAE LVNSGEDVLV FYNDRASFQT LIQMMRSERD
     RMDENSPLMY HIHLVELLAV CTEGKNVYTE IKCNSLLPLD DIVRVVTHED CIPEVKIAYI
     NFLNHCYVDT EVEMKEIYTS NHMWKLFENF LVDICRACNN TSDRKHADSI LEKYVTEIVM
     SIVTTFFSSP FSDQSTTLQT RQPVFVQLLQ GVFRVYHCNW LMPSQKASVE SCIRVLSDVA
     KSRAIAIPVD LDSQVNNLFL KSHNIVQKTA MNWRLSARNA ARRDSVLAAS RDYRNIIERL
     QDIVSALEDR LRPLVQAELS VLVDVLHRPE LLFPENTDAR KKCESGGFIC KLIKHTKQLL
     EENEEKLCIK VLQTLREMMT KDRGYGEKLP QALEPENSTE GEALRQILVN RYYGNVRPSG
     RRESLTSFGN GPLSPGGPSK PGGGGGGSGS SSTSRGEMSL AEVQCHLDKE GASNLVIDLI
     MNATSDRVFH ESILLAIALL EGGNTTIQHS FFCRLTEDKK SEKFFKVFYD RMKLAQQEIK
     ATVTVNTSDL GNKKKDDEVD RDAPSRKKAK EPSTQITEEV RDQLLEASTA TRKAFTTFRR
     EADPDDHYQP GEGTQATTDK TKDDLEMSAV ITIMQPILRF LQLLCENHNR DLQNFLRCQN
     NKTNYNLVCE TLQFLDCICG STTGGLGLLG LYINEKNVAL INQTLESLTE YCQGPCHENQ
     NCIATHESNG IDIITALILN DINPLGKKRM DLVLELKAIC ASKHMCLFDP DQNNASKLLL
     AIMESRHDSE NAERILYNMR PKELVEVIKK AYMQGEVEFE DGENGEDGAA SPRNVGHNIY
     ILAHQLARHN KELQTMLKPG GQVDGDEALE FYAKHTAQIE IVRLDRTMEQ IVFPVPSICE
     FLTKESKLRI YYTTERDEQG SKINDFFLRS EDLFNEMNWQ KKLRAQPVLY WCARNMSFWS
     SISFNLAVLM NLLVAFFYPF KGVRGGTLEP HWSGLLWTAM LISLAIVIAL PKPHGIRALI
     ASTILRLIFS VGLQPTLFLL GAFNVCNKII FLMSFVGNCG TFTRGYRAMI LDVEFLYHLL
     YLLICAMGLF VHEFFYSLLL FDLVYREETL LNVIKSVTRN GRSIILTAVL ALILVYLFSI
     VGYLFFKDDF ILEVDRLPNE TAVPETGESL ASEFLYSDVC RVESGENCSS PTPKEELVPV
     EEMEQDKEHT CETLLMCIVT VLSHGLRSGG GVGDVLRKPS KEEPLFAARV IYDLLFFFMV
     IIIVLNLIFG VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVT FEEHIKEEHN
     MWHYLCFIVL VKVKDSTEYT GPESYVAEMI KNLGVRHALR EKHMLAKEVR REEEQPILLT
     STKKVHRCEL VTSSKDRDMG GNRMGLPYTN GQHPSAI
//
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