ID A0A091CUD3_FUKDA Unreviewed; 1013 AA.
AC A0A091CUD3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Chloride channel protein 1 {ECO:0000313|EMBL:KFO22097.1};
GN ORFNames=H920_16477 {ECO:0000313|EMBL:KFO22097.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO22097.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO22097.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO22097.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN124131; KFO22097.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091CUD3; -.
DR STRING; 885580.ENSFDAP00000009570; -.
DR eggNOG; KOG0476; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002243; Cl_channel-1.
DR PANTHER; PTHR45720:SF4; CHLORIDE CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01112; CLCHANNEL1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 3.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 801..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..921
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 111149 MW; 38337527EA293A68 CRC64;
MERPPSQRHG GEQSWWGSAP QYQYMPFEHC TSYGLPSENG GIQHRPQKDA GPRHNVHPTQ
IYGHHKEQFL DKEQDIRIPK NMGSSSSLDS KNEDHYSKCQ GCIHRLECMV RRKLGEDWIF
LVLLGLLMAL VSWCMDYVSA KSLQAYKWTY AQVQPNLPLQ YLVWVTFPLV LILFSALFCH
LISPQAVGSG IPEMKTILRG VVLKEYLTLK AFVAKVVALT AGLGSGIPVG KEGPFVHIAS
ICAAILSKFM AMFCGVYEQP YYYTDMLTVG CAVGVGCCFG TPLGGKCTFH ISLPAWFHPP
NGFGRPHQVL DLATFLQQEQ LSSRVLFSIE VTSTYFAVRN YWRGFFAATF SAFVFRVLAV
WNKDAVTITA LFRTNFRMDF PFDLQELPAF AVIGSVGPPG VGVVSREWGD CGLEGQRVRG
HGICCGFLGA VFVYLHRQVM LGVRKHKALS QFLAKHRLLY PGIVTFVIAS CTFPPGMGQF
MAGELMPREA ISTLFDNNTW VKHEGDPKSL GQSAVWIHPR VSVVIIILLF FIMKFWMSIV
ATTMPIPCGG FMPVFVLGAA FGRLVGEIMA MLFPEGILFD DIIYKILPGG YAVIGAAALT
GAVSHTVSTA VICFELTGQI AHILPMMVAV ILANMVAQSL QPSLYDSIIQ VKKLPYLPDL
GWNQLSKFTI VVEDIMVRDV KFVSASCTYG ELRNLLQATT VKTLPLVDSK DRPERGTVWV
GAGADHGSPP DSRILLGSVE RSELQSLLQR HLCPERRLQE ARDLALKLSE LPYDGKVRLS
GDRFLDGAPR GRPESFAFVD EDEDEDLSSK TELPPPPPLP NFASVPSSSE EPNGPLTGHK
QSPEAPEPAG QRSSIFQCLL HCLLGRAHPP KKKTTQDSMD LVDNMSPEEL QKAIEGHTKS
GVQLRPPLAS FRNTNTSLKS PGGPPPLAEG WGLPEDAAGL PGTGDLTPAS PETPVPPPSP
DATLALALAK AGGELEELEL VESPGLEEEL ADILQGPSLR STDEEEDEDE LIL
//
