ID A0A091CUF9_FUKDA Unreviewed; 1455 AA.
AC A0A091CUF9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Keratin, type II cytoskeletal 1 {ECO:0000313|EMBL:KFO21255.1};
GN ORFNames=H920_17303 {ECO:0000313|EMBL:KFO21255.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21255.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21255.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21255.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KN124398; KFO21255.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000011128; -.
DR eggNOG; ENOG502QQIF; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 3.
DR Gene3D; 1.20.5.500; Single helix bin; 2.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 3.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF33; KERATIN, TYPE II CYTOSKELETAL 1; 1.
DR Pfam; PF00038; Filament; 4.
DR Pfam; PF16208; Keratin_2_head; 3.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 3.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 8.
DR PROSITE; PS00226; IF_ROD_1; 3.
DR PROSITE; PS51842; IF_ROD_2; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 140..453
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 665..978
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 1198..1455
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 351..424
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 720..810
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 876..956
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1281..1434
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1455 AA; 158402 MW; 12A1180928C162F0 CRC64;
MPLEFQLDSG LPTNANLQRN TVNAEHDGEG TLKDTNAKLH DLKVALQQAR EDLARDLSPS
PSDLGPSPIF PDGWHSSSKA VGKTDLVEKP LIHRASNFGP GGFGPSYPPG GIREVTINQS
LLEPLHLEVD PEIQRIKIQE REQIKVLNNK FASFIDKVRF LEQQNQVLQT KWELLQQVDT
TTQNSNLESF FESYISGLQK KVDFLNNEQM RKNSEIRSMQ DTVEDYKSKY EEEINKRTSA
ENDFVVLKKD VDAAYVSKTD LESKVDTLLG EVNFLKYLFQ MELSQMQTHI SDTNVILSMD
NNRTLDLDSI IEAVQAEYEL IVQRSKDEAE MLYQTKYQEL QISAGRQGDD LKNTKMEIAE
LNRNIQRLQA EIGSVKKQIE QMHSAISDAE ERGQQALEDA KQKLQDMDEA LQQSKESLAR
LLRDYQAMLG AKLSLDVEIA TYRKLLECEE SRMSGEMQNQ VSISVESNQV TLSGGAAGGS
GGYGGGGGYS GGGGNFGANM SRQYSSRSLC RSGGKGFSSG SAGLVSFQRR STSSVRRSGG
GGGRFSGGFC GSGGGGGGFG SRSLINLGGS KSISINVAGG GSRSGFGYGG GVFGGGVFGG
GVFGGGGLGG GNFGSGGGFG GGGYGGGFGP VCPPGGIQEV TINQSLLQPL NVEIDPEIQK
IKSQEREQIK TLNNQFASFI DKVRFLEQQN QVLQTKWELL QQVDTSTRSF SLEPYFEAYI
SDLRKQVDRL RSDQSRMDSE LKTMQDMVED YRNKYEDEIN KRTNAENEFV TIKKDVDSAY
MNKVDLQAKV DNLRQEIDFL TALYEAELSQ MQTHISETSV ILSMDNNRSL DLDSIIAEVK
AQYEDIAQRS KAEAEALYQT KYEELQVTAG KHGDSVKTSK MEISELNRVI QRLRSEIDSV
KKQISQLHQS IADAEQRGEN ALKDAQNKLN ELEDALQQAK EDLARLLRDY QELMNVKLAL
DVEIATYRTL LEGEESRMSG ECSANVSMSL ALIRNLQVSS LYKAIMSCQN SCKSRGGVGG
GGGRRGGGGG GGGFRGFSSG SAIVSGGSRR STSSFSCLSR HGGGGGGRGG GCGAGGFGSQ
SVVSLGGSKS ISICVAGRGG SFGSGGGFGG RGGSFGGFGG GSSFGGGSGF GGGGFVGGSV
GGGRFGGGGG PGGFGGPGGF GPGGILGGGI HEVSVNQSLL QPLDVKVDPE IQNIKSQERE
QIKALNNKFA SFIDKVRFLE QQNQVLKTKW DLLQQLDVRS RTTNLEPLFQ TYISLLLKQV
DTLSSERTAQ DSELNHMHDL VEDYKKKFED EINKRTAAEN DFVTLKKDVD NGYTIKVALQ
ANVEALAQEI DFLRRLYEEY EELQLVAGKH GDSLREIKME ISELNRMIQR LQGEISHVKK
QCKCVQDAIA EAEQRGEHAI KDAQQKLIDL EEALQQARED LARLLRDYQE LMSTKLSLDI
EIATYRKLLE GEECR
//
